齐拉西酮对精神分裂症患者生活质量的影响

Influence of Ziprasidone on Quality on Life of Patients with Schizophrenia

目的:探讨齐拉西酮对精神分裂症患者生活质量的影响。方法:80例精神分裂症患者随机平分为两组,分别给予齐拉西酮和利培酮治疗,疗程12周。采用阳性和阴性症状量表(PANSS)、不良反应量表(TESS)进行疗效、不良反应评定;采用生活质量量表(QOL-100)进行生活质量评估。结果:阿立哌唑与利培酮对精神分裂症的阳性症状、阴性症状的改善相似,PANSS评分两组间差异无统计学意义;齐拉西酮组不良反应发生率低于利培酮组;齐拉西酮组QOL-100各因子除精神支柱外均明显改善,在生理因子、心理因子、独立性因子、环境因子较利培酮组改善显著。结论:齐拉西酮治疗精神分裂症与利培酮的疗效相当,但不良反应少,能够显著改善患者的生活质量。

Objective： To investigate the efficacy of ziprasidone on life quality of patients with schizophrenia. Methods ： Schizophrenic patienst who were treated by ziprasidone （n = 30） or risperidone （n = 30） were evaluated with positive and negative symptom scale （PANSS）, treatment emergent symptom scale （TESS） and WHO Quality of Life- 100 （QOL- 100） for 12 weeks. Results： The clinical efficacy had no significant difference between the two groups. The scores of PANSS in two groups after treatment were lower significantly than those before treatment, but the scores of PANSS had no significant difference between the two groups. The incidence of adverse effect in the ziprasidone group was lower than that in the resperidone group. The scores of QOL - 100 in the ziprasidone group were higher significantly than those in the resperidone group after treatment for 12 weeks. Conclusions： Ziprasidone is as effective as resperidone in the treatment of schizophrenia, with less adverse effect, and can significantly improve the llfe quality of the schlzophrenics.