植物甾醇及其环糊精包合物对高血脂小鼠降血脂实验研究

Study on the experiment of reducing blood lipid of high blood cholesterolin mice for phytosterol and its cyclodextrin inclusion complexes

目的:评价植物甾醇经过β-环糊精及其衍生物包合作用对高血脂症小鼠血脂指标的影响。方法:将昆明小鼠分为6组,分别为正常组、高脂模型组、阳性对照组、植物甾醇组、β-环糊精/植物甾醇包合物组和羟丙基-β-环糊精/植物甾醇包合物组,建模给药测定其血脂水平。结果:给予不同药后,与模型组比较,阳性对照组和三个实验组均能显著降低TC、LDL-C和AI水平,提高HDL-C水平,且三个实验组之间各指标均没有显著性差异。结论:植物甾醇有显著的降血脂作用,而且经过β-环糊精和羟丙基-β-环糊精包合后不影响其降血脂功能。

Objective：Evaluated the influence of phytosterol that was inclusion by β-cyclodextrin and its derivative to serum lipid indexes of mice of hyperlipidemia.Method：72 Kunming mice were randomly divided into six groups：normal group,model group,positive control group,phytosterol group,phytosterol/β-cyclodextrin inclusion group,phytosterol/hydroxypropyl-β-cyclodextrin inclusion group,after the model built and drug delivered then analysed of serum lipid level in mice.Results：After medication,comparing with the model group,the level of serum TC,LDL-C,AI decreased and HDL-C was improved obviously in positive control group and the three experimental groups,while there were no significant differences of the serum lipid indexes among the three experimental groups.Conclusion：The result shows that the phytosterol had obvious action of reducing blood lipid.And there had no influence on that when it was included by β-CD or HP-β-CD.