新型磺酰胺手性配体的合成与表征

Synthesis and characterization of novel sulfonamide chiral ligands

以天然L-缬氨酸为手性源,通过保护氨基、缩合、去保护、还原、酰化等简单步骤合成了3种新型的磺酰胺类手性配体。该类反应具有后处理简单、反应温和、产率高等优点。并利用1HNMR、13CNMR、ESI/MS对合成的目标产物进行了表征及结构确认,并初步探索了该类型配体在催化二乙基锌对醛的不对称加成反应中的应用。

Three novel sulfonamide chiral ligands were synthesized from natural L-valine through functional group protection,condensation,deprotection,reduction and acylation.The method has such advantages as simple operation,mild reaction conditions and high product yield.The structures were confirmed by 1HNMR,13CNMR and ESI/MS.Some initial work has been done for enantioselective of diethylzinc addition to benzaldehyde using these chiral ligands.