哌仑西平短程治疗消化性溃疡23例

Pirenzepine in short term clinical trial of peptic ulcer in 23 patients

本文应用哌合西平(50mg,bid)治疗消化性溃疡23例与西咪替丁(1.0g/d)组26例进行对照研究。疗程均为6wk,由内窥镜检查评定疗效。结果表明,哌仑西平与西咪替丁2组溃疡愈合有效率分别为61％(14/23)与81％(21/26);2组止痛有效率分别为65％(15/23)与33％(6/18),均无统计学差异。因此,哌仑西平对消化性溃疡的疗效与西咪替丁相似。哌仑西平组的不良反应有口干、视力模糊等,似较西咪替丁组为多。

Forty-nine patients with active peptic ulcer were admitted to a short term trial to compare the efficacy of pirenzepine(23 patients, 50 mg bid)with cime-tidine(26 patients, 1.0g/d).Cimetidine was used as control. After a courseof treatment (6wk), all patients were reexamined endoscopically. Peptic ulcer were healed in 14 out of 23 patients treated with pirenzepine and 21 out of 26 patients treated with cime-tidine. The difference was not statistically significant (P>0.05). Epigastric pain was controlled in 15 out of 23 patients received pirenzepine and G out of 18 patients received cimetidine. Adverse reactions were observed in pirenzepine group, especially in the dryness of mouth and the blurring of vision.