痰湿型多囊卵巢综合征血清抗苗勒氏管激素水平的研究

Anti-MüLlerian Hormone Study of of Polycystic Ovary Syndrome with Phlegm-Dampness

目的:探讨多囊卵巢综合征痰湿证临床及性激素、抗苗勒氏管激素(AMH)的特征性,从而为多囊卵巢综合征的中医规范化诊治提供依据。方法:以50例正常育龄妇女为对照组,150例PCOS患者分为两组:非痰湿组、痰湿组,其中非痰湿组99例,痰湿组51例,化学发光法测定血清性激素水平及AMH水平,同时比较3组初潮年龄、月经周期、BMI、腰围、SBP、DBP等临床指标的差异性。结果:①各组间临床特征比较:月经周期PCOS两组与对照组比较均有显著性差异(P<0.05);BMI、腰围PCOS痰湿组与对照组及非痰湿组比较均有显著性差异(P<0.05)。②各组间性激素及AMH的比较:LH、T、AMH值PCOS两组与对照组比较均有显著性差异(P<0.05);血清AMH值PCOS两组间比较也有显著性差异(P<0.05)。结论:多囊卵巢综合征痰湿证在BMI、腰围、AMH等水平具有特征性表达,提示痰湿证有胰岛素抵抗的倾向性。

Objective：To explore the characteristics of sex hormone and Anti -Miillerian hormone （AMH）in PCOS pa- tients with phlegm -dampness in order to give further basis on standardized diagnosis and teatment of PCOS. Methods ：50 normal reproductive- aged women as controls, and 150 PCOS patients were divided into two groups： phlegm- dampness group and non phlegm- dampness group. Serum sex hormone, as well as AMH levels were measured by Chemilumines- cence. Indeics above and other parameters （ menstrual cycle, BMI, waist size, etc were compared among groups. Results ： （1）clinical characteristics ： menstrual cycle ： PCOS groups 〉 control; BMI, waist size ： phlegm - dampness PCOS group 〉 control, phlegm - dampness PCOS group 〉 non phlegm - dampness group （P 〈 0. 05 ）. （2）sex hormone and AMH ： LH, T, AMH levels： there were significant difference between PCOS groups and control, there were also significant difference of AMH between phlegm - dampness PCOS and non phlegm - dampness PCOS group （ P 〈 0. 05 ）. Conclusions ： There were characteristic expression on BMI, waist size, AMH in phlegm - dampness PCOS patients, they might have insulin resistance tendency.