当归补血汤对糖尿病肾病患者肾脏保护的研究

The Review of of Angelicae Sinensis Decoction for Supplementing Blood Protective the Kidney of Diabetic Nephropathy

目的:研究当归补血汤对糖尿病肾病患者肾脏功能的影响,探讨其在糖尿病肾病(DN)防治中的意义。方法:(1)将符合条件的121例患者随机分为常规治疗组(对照组)和当归补血汤组(治疗组)(在对照组基础上另给予黄芪30g,当归6g,并根据中医症型加减),治疗4周后对比两组的空腹血糖(FBS)、餐后2h血糖、血尿酸(UA)、肌酐(Cr)、尿素氮(BUN)、糖化血红蛋白(HbA1C)、体重指数(BMI)、24h尿微量白蛋白等的变化情况。结果:当归补血汤治疗组肾功能改善优于对照组(P<0.05),24h尿微量白蛋白排出明显低于对照组(P<0.01),但在BMI、FBS、HbA1C及餐后2h血糖疗效无差别(P>0.05)。结论:归补血汤能改善糖尿病肾病患者肾功能,减少尿蛋白的排出。

Objective： To investigate the effective of Angelicae Sinensis Decoction for Supplementing Blood （one kindof traditional prescription of chinese herbal medicine） on renal functions in patients with diabetic nephropathy, and explore the significance of the prevention and treatment in diabetic nephropathy. Method： （1）. The 121eligible patients were randomly divided into conventional treatment group （control group） and and Angelicae Sinensis Decoction for Sup- plementing Blood group （treatment group） （based on the control group, given Astragalus 30g, Angelica 6g disease ac- cording to type addition and subtraction, modified according to the illness of Chinese medicine type）, comparing the two groups after 4 weeks of treatment, fasting blood glucose （FBS）, postprandial two- hour blood glucose, serum uric acid （UA）, creatinine （Cr）, blood urea nitrogen （BUN）, glycated hemoglobin （HbA1C）, body mass index （BMI）, 24 - hour urine albumin and other changes. Results： The group of Angelicae Sinensis Decoction for Supplementing Blood im- proved renal function than the control group（P 〈 0.05） , 24 - hour urine albumin was significantly lower than the control group discharge （P 〈 0. 01 ） , but BMI, FBS, HbA1 C, and the postprandial two -hour blood glucose effect of no differ- ence （P 〉 0.05 ）. Conclusion： Angelicae Sinensis Decoction for Supplementing Blood Can improve renal function in pa- tients with diabetic nephropathy, reduce urinary protein excretion.