摘要
目的:研究心理应激法诱导腹泻型肠易激综合征(IBS)大鼠模型内脏敏感性的变化,探讨肠易激综合征的发病机制及宁肠汤治疗肠易激综合征的机理。方法:SD雄性大鼠72只随机分为正常对照组、模型对照组、得舒特组、宁肠汤低、中、高剂量组6组,观察各组大鼠在不同容量下行直肠扩张AWR评分变化,观察宁肠汤的干预作用。结果:(1)各组大鼠的体重增长变化率差异无显著性意义(P>0.05);(2)慢性束缚应激+夹尾刺激诱导IBS大鼠内脏敏感性明显增高(P<0.01)。宁肠汤能降低IBS大鼠内脏敏感性的AwR评分(P<0.05~0.01),且有一定的量效关系,以高剂量组的效果最为明显。结论:宁心安神法对心理应激致IBS大鼠的内脏高敏感性有一定的调节作用。
Objective : researching the change of visceral sensitivity of the D - IBS rats within the chronic psychological Stress. To discuss the probable way and mechanism of the Ningchangtang preventing and treating IBS. Methods:72 SD rats were randomly divided into 6 groups : blank control group, model control group, western medicine group, Ningchang- tang small, medium, large dosage groups. To observe the score of AWR for each experimental group, studying the effect of Ning chang tang. Results : (1) The weight growth - rate in each groups showed no significant difference ( P 〉 0, 05 ). (2) The visceral sensitivity of the D - IBS rats within the chronic Psychological Stress markedly enhanced( P 〈 0.01 ). The score of AWR were obviously lowered (P 〈 0.05 -0.01 ) by using Ning chang tang and its action was of dose -depend- ent, especially the effect of high dosage group. Conclusion : The Ning chang tang can effectively regulate the change of vis- ceral hypersensitivity of D - IBS rats within the chronic Psychological Stress.
出处
《中华中医药学刊》
CAS
2011年第9期2127-2130,共4页
Chinese Archives of Traditional Chinese Medicine
关键词
肠易激综合征
内脏高敏感性
宁心安神法
Irritable bowel syndrome
visceral hypersensitivity
the method of Ning - xin An - shen