交沙霉素的抗菌作用及临床治疗各种细菌感染34例

Antibacterial activity and clinical efficacy of josamycin in 34 patients with various infections

本文测定了交沙霉素的体外抗菌作用。43株表皮葡萄球菌(表葡菌)和金黄色葡萄球菌(金葡菌)对交沙霉素和红霉素敏感率分别为81％和54％。交沙霉素对26株厌氧葡萄球菌(消化球菌)、消化链球菌和28株类杆菌的MIC_(50)分别为0.5和2mg/L。交沙霉素对34例口腔、五官及皮肤的感染全部有效,其中显效(痊愈)占88％。31例获细菌33株,细菌转阴率为97％。治疗中仅3例出现头晕和轻度消化道反应。

Antibacterial activity of josamycin was determined. Sensitivity rates of 43 strains of S.aurens and S.epidermidis for josamycin and erythromycin were 81% and 54% respectively. MIC50s of josamycin against 26 strains of Peptococcus and Pep-tostreptococcus, and 28 strains of Bacteroides were 0.5 and 2 mg/L respectively. Thirty-four patients with boils, nasal sinusitis, otitis or oral infection were treated with josamycin. Thirty patients were cured and 4 improved. Thirty three strains were isolated in 31 patients. The pathogen was eradicated in all but 1 patient. Mild dizziness, epigastric pain and nausea occurred one each in 3 patients .