真菌性阴道炎假丝酵母菌属临床分布及药敏分析

Clinical distribution of Candida and their drug sensitivity

目的探讨真菌性阴道炎假丝酵母菌属临床分布和药敏试验结果。方法回顾性分析1628例阴道炎患者的临床资料,进行真菌培养,药敏试验采用K-B纸片法。结果分离出假丝酵母菌属8种133株,阳性率为8.17%,以白色假丝酵母菌为主占64.66%。假丝酵母菌对特比萘芬的耐药率较高为43.61%、氟康唑为27.82%、伊曲霉唑为21.05%、制霉菌素为3.76%和两性霉素为6.77%。结论真菌性阴道炎感染以白色假丝酵母菌为主,并呈现出多药耐药特点,应根据药敏结果选择合理的抗真菌药物。

OBJECTIVE To explore the clinical distribution of Candida and their drug sensitivity in patients with fungal vaginitis.METHODS The clinical data of 1628 cases with vaginitis were reviewed.The vaginal discharge were cultured and the drug sensitivity was tested by K-B Disk diffusion.RESULTS Totally 133 strains of 8 species of Candida were isolated,and the positive rate was 8.17%.Candida albicans was the main fungi（64.66%）.They showed high drug-resistance to terbinafine（43.61%）,fluconazole（27.82%） and itraconazole（21.05%）,but sensitive to nystatin（3.76%） and amphotericin（6.77%）.CONCLUSION Fungal vaginitis is mainly infected by Candida albicans,and the Candida show multiple drug resistance.We should choose reasonable antifungal drugs according to the drug sensitivity result.