临床分离的112株铜绿假单胞菌对常用抗菌药物的敏感性检测分析

Analysis on the Sensitivity of 112 Pseudomonas Aeruginosas(PAEs)Isolated from Clinic to the Common Antibacterial Drugs

[目的]了解临床分离的铜绿假单胞菌（PAE）的耐药性,为PAE感染者的治疗提供依据。[方法]对山东大学齐鲁儿童医院2010年1~8月从门诊、住院病人标本中检出的112株铜绿假单胞菌进行药物敏感性检测。[结果]检测112株铜绿假单胞菌,对头孢派酮/舒巴坦、美罗培南均敏感,对亚胺培南、妥布霉素的敏感率分别为98.21%、96.43%,对头孢吡肟、哌拉西林、头孢他啶、替卡西林/克拉维酸的敏感率分别为89.29%、89.29%、84.82%、82.14%,对复方新诺明的敏感率为17.86%,对头孢噻肟的敏感率为20.54%。[结论]临床标本分离的铜绿假单胞菌对头孢派酮/舒巴坦、美罗培南、亚胺培南、妥布霉素较为敏感,对复方新诺明、头孢噻肟的耐药率很高。

[Objective]To understand the drug resistance of Pseudomonas aeruginosa（PAE） isolated f rom clinic,so as to provide basis for clinical therapy of PAE infection.[Methods]Undertaking a drug sensitive test for the 112 PAEs isolated from specimens of the outpatients and inpatients of Qilu Children’s Hospital,Shandong University from Jan,2010 to Aug,2010.[Results]112 PAEs were equally sensitive to cefoperazone/Sulbactam,meropenem.The respective sensitivity rate to imipenem and tobramycin was 98.21% and 96.43%.The respective sensitivity rate to cefepime,piperacillin,ceftazidime,ticarcillin/clavulanic acid was 89.29%,89.29%,84.82% and 82.14%.The sensitivity rate to cotrimoxazole was 17.86%.The sensitivity rate to cefotaxime was 20.54%.[Conclusion]The PAEs isolated from clinical specimens have a relatively high sensitivity rate to cefoperazone /sulbactam,meropenem,imipenem,tobramycin and a relatively high drug resistance rate to cotrimoxazole and cefotaxime.