氪激光联合迈之灵治疗缺血性视网膜中央静脉阻塞的研究

The clinical study of treatment for ischemic type of central retinal vein occlusion by Krypton laser and Aescuven forte

目的探讨氪离子激光联合药物迈之灵治疗缺血性视网膜中央静脉阻塞的疗效。方法临床病例对照研究。对2006年1月至2009年1月在广西医科大学第一附属医院眼科就诊的病人，分为两组。实验组：对随机选取的30例确诊为缺血型CRVO的病人，以氪离子激光行全视网膜光凝术，并予以口服药物迈之灵进行治疗。对照组：对另外随机选取的30例确诊为缺血型CRVO的病人，予以单纯行氪离子激光全视网膜光凝术。观察两组病人治疗后眼底出血、水肿、渗出、新生血管和视力的变化情况等。结果实验组和对照组治疗后视力改善差异无统计学意义；实验组在激光治疗的同时给予口服药物迈之灵治疗后一月复查眼底，其出血、水肿及渗出吸收情况优于对照组，差异有统计学意义；三月后复查眼底及FFA，两组眼底出血、水肿、渗出的吸收及新生血管的消退情况差异无统计学意义。结论对于缺血性视网膜中央静脉阻塞，采用全视网膜光凝术预防和治疗新生血管是防止严重并发症的重要手段，迈之灵的联合应用可以相对缩短眼底出血、水肿和渗出的吸收时间。

Objective To investigate the effect of Krypton laser and Aescuven forte treatment on ischemic type of center retinal vein occlusion. Methods A prospective randomized clinical study. The 30 patients of ischemic CRVO received the treatment with Krypton laser PRP and Aescuven forte as an experimental group. Another 30 patients of ischemic CRVO received only the treatment with PRP Krypton laser as control group. The changes of hemorrhage, edema, effusion and neovascularization in fundus and the change of visual acuity were observed. Results The visual acuity of experi- mental group and control group had＇ no statistic difference. After one month the changes of hemorrhage, edema and effusion of experimental group were statistically different fi＇om the control group. After three months, the changes of hemorrhage, edema, effusion and neovascularization of two groups had no statistic difference. Conclusions To ischemic type of CRVO, it is an important method to apply PRP to prevent and treat neovascularization and serious complications. The application of Aescuven forte can shorten the absorbed time of hemorrhage, edema and effusion.