未分化结缔组织病的研究进展

Update on undifferentiated connective tissue diseases

未分化结缔组织病是临床实际存在的一种疾病状态，目前发病机制尚不清楚。未分化结缔组织病的临床特征为具有自身免疫病的症状和体征，只有一种自身抗体阳性，不符合任何结缔组织病的诊断标准。演变是未分化结缔组织病疾病过程中最为突出的特点，30％可演变为结缔组织病，70％维持未分化结缔组织病的状态。经未分化结缔组织病演变而来的结缔组织病，病情相对轻微，重要器官损害较少。疾病特点和演变结果提示，未分化结缔组织病是自身免疫性疾病疾病谱中重要一员。

Undifferentiated connective tissue diseases are an actually existing clinical disease state of unknown origin. They clinically resemble autoimmune diseases with the presence of a kind of autoantibody, which does not meet the diagnostic criteria for any defined connective tissue disease. Evolution is the most prominent feature of undifferentiated connective tissue diseases, of which, 30% could evolve into connective tissue diseases, 70% remain in the initial state. The severity of connective tissue diseases evolving from undifferentiated connective tissue diseases tends to be mild with low-grade major organ injury. Clinical manifestations and evolution process reveal that undifferentiated connective tissue diseases are an important member in the spectrum of autoimmune diseases.