中国汉族女性人群成纤维细胞生长因子受体2基因多态性与乳腺癌易感性的研究

Study of the susceptibility between the FGFR2 gene polymorphism and the breast cancer risk in Chinese Han nationality female population

目的探讨中国汉族女性成纤维细胞生长因子受体2(FGFR2)基因多态性与乳腺癌易感性的关系。方法通过检索PubMed,EMBASE和CNKI数据库中有关FGFR2基因与乳腺癌易感性相关的文献,收集、整理中国汉族女性乳腺癌病例和正常对照的基因型数据,进行Meta分析和关联研究。结果 FGFR2的4个多态位点(rs2981582、rs1219648、rs2420946和rs2981579)的Meta分析结果显示优势比(OR)(95%CI区间)分别为1.25(1.15～1.36)、1.13(0.96～1.34)、1.12(1.02～1.23)和0.99(0.82～1.20);基因型的关联研究相应的概率P值分别是0.000002、0.0002、0.006和0.998。结论 FGFR2基因的rs2981582、rs2420946多态性增加了中国汉族女性人群患乳腺癌的危险,rs2981579位点与乳腺癌易感性无关联,需要进一步证明rs1219648位点与乳腺癌易感性的关相程度。

Objective To explore the susceptibility between the fibroblast growth factor receptors 2（FGFR2） gene polymorphism and the breast cancer risk in the Chinese Han nationality female population.Methods By searching literatures in the PubMed,EMBASE,and CNKI databases which were related to the FGFR2 gene polymorphism and the breast cancer rick in the Chinese Han nationality female population,the genotype data of both breast cancer patients and the controls were collected,followed by the Meta-analysis and the association studies.Results Meta-analysis revealed that OR（95% CI interval） of four polymorphic loci alleles（rs2981582,rs1219648,rs2420946 and rs2981579） of FGFR2 gene were 1.25（1.15~1.36）,1.13（0.96~1.34）,1.12（1.02~1.23） and 0.99（0.82~1.20）,respectively.The probability P values of the association studies were 0.000002,0.0002,0.006 and 0.998 respectively.Conclusion The rs2981582 and rs2420946 polymorphisms of FGFR2 gene increase the breast cancer risk in Chinese Han female population.Rs2981579 locus is not associated with breast cancer risk.Further study is needed to explore the association strength between the rs1219648 polymorphisms and the breast cancer risk.