连接蛋白Connexin 43在鼻息肉中的表达

Connexin 43 expression in nasal polyps

目的:研究连接蛋白43(Connextio 43,Cx43)在正常鼻黏膜和鼻息肉中的表达,探讨鼻息肉的发病机制。方法:采用免疫组织化学染色和平均光密度检测技术,对30例鼻息肉和10例正常鼻黏膜组中Cx43的表达进行分析。结果:连接蛋白Connexin 43主要表达于黏膜及黏膜下组织,正常鼻黏膜表达最明显(P<0.01),鼻息肉中表达相对于正常鼻黏膜中表达普遍减少。结论:连接蛋白Connexin 43在鼻黏膜和鼻息肉中均表达,且主要集中在黏膜和黏膜下组织,Cx43在鼻息肉中表达下调可能与鼻息肉的发生存在着某种密切的联系。

Objective：To study the expression of connexin 43（Cx43） in nasal polyps.Meanwhile,to approach the nosogenesis of nasal polyps.Methods：The expression of Cx43 in 30 cases of nasal polypus and 10 cases of normal nasal mucous membrane were observed by the way of quantitate and semiquantitative analysis under the optical microscopy and technology of immunohistochemistry staining.Results：Connexin 43 expressed mainly under the nasal mucous and submucous tissue.The most in normal nasal membrana mucosa contrast on the expression of connexin 43 in nasal polyps（P〈0.01）.Conclusion：Connextin 43 is present in both the normal nasal membrana mucosa and nasal polyps,The nosogenesis of nasal polyps may be intimate correlated with connexin 43 expression down regulation in nasal polyps.