米非司酮配伍卡前列甲酯栓终止孕12～16周妊娠疗效观察

Efficacy observation of mifepristone combined with carboprost methylate suppositories on ending 12-16-week pregnancy

目的:探讨米非司酮配伍卡前列甲酯栓终止孕12～16周妊娠的疗效。方法:选择2010年1月～2011年6月来本院要求终止妊娠的孕12～16周的孕妇120例,按照随机对照的原则将其分为观察组和对照组各60例。观察组服用米非司酮50mg,早晚各1次,连服2d,后于阴道后穹隆放置卡前列甲酯栓1mg;对照组采用羊膜腔内注入利凡诺100mg终止妊娠;观察比较两组的临床疗效和安全性。结果:观察组完全流产率为85.00%,对照组为66.67%,两组比较,差异有统计学意义(P<0.05);流产时间观察组为(6.42±2.31)h,对照组为(60.54±3.90)h,两组比较,差异有统计学意义(P<0.05);阴道出血量观察组为(34.67±5.21)ml,对照组为(78.69±21.34)ml,两组比较,差异有统计学意义(P<0.05)。结论:米非司酮配伍卡前列甲酯栓终止孕12～16周妊娠效果优于利凡诺羊膜腔内注射,值得临床推广应用。

Objective： To study the effect of mifepristone combined with carboprost methylate suppositories on ending 12-16-week pregnancy. Methods： 120 cases pregnant women who had 12-16-week pregnancy in hospital from Junary 2010 to June 2011 were slected and required to ending pregnancy. The 120 patients were randomly divided into observation group 60 cases and control group 60 cases. The observation group were given mifepristone 50 mg, one time at morning and night, 2 days later, 1 mg carboprost methylate suppositories was layed in posterior fornix of vagina; The control group were given rivanol 100 mg amniotic membrane cavity injection to ending pregnancy. Observed the efficient and safty of the two groups. Results： The complete abortion rate of observation group was 85.00%, the control group was 66.67%, there was significant difference between two groups （P〈0.05）; The arbortive time of observation group was （6.42±2.31） h, the control group was （60.54±3.90） h, there was significant difference between two groups （P〈0.05）; The vaginal bleeding volume of observation group was （34.67±5.21） ml, the control group was （78.69±21.34） ml, there was significant difference between two groups （P〈0.05）. Conclution： The efficacy of mifepristone combined with carboprost methylate suppositories on ending 12-16-week pregnancy is better than rivanol amniotic membrane cavity injection, it is worthy of clinical popularization and application.