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创伤性脑损伤后大鼠脑创伤区皮层细胞早期凋亡的实验研究 被引量:3

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摘要 目的探讨不同程度颅脑损伤后大鼠脑创伤区皮层细胞早期凋亡的规律及意义。方法健康成年雄性Wistar大鼠48只,随机分为3组,即轻度组,中度组和重度组。Feeney法制作自由落体颅脑损伤(TBI)动物模型,伤后1h采用流式细胞仪(FCM)碘化丙啶(PI)单染色法检测大鼠脑创伤区皮层细胞亚二倍体比率。结果轻度、中度和重度TBI组的创伤区皮层细胞亚二倍体比率分别为(8.98±1.29)%、(16.13±1.28)%和(20.11±1.40)%,损伤程度越重,亚二倍体比率越高(P<0.01)。结论不同程度颅脑损伤后大鼠创伤区脑组织细胞早期凋亡存在一定规律,它与脑细胞的变性坏死共同作用引起一系列继发性脑损伤,加重创伤后的脑神经功能障碍。
出处 《中西医结合心脑血管病杂志》 2011年第9期1094-1095,共2页 Chinese Journal of Integrative Medicine on Cardio-Cerebrovascular Disease
基金 国家自然基金资助项目(No.30600637)
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参考文献10

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同被引文献35

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