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诱导性多能干细胞研究进展及应用前景 被引量：2

The Progress and Prospect of Induced Pluripotent Stem Cells
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摘要 将体细胞或成体干细胞重编程转变为诱导性多能干细胞(iPSCs)技术是近年来再生医学领域的重大进展。它是通过人工方法将适当的外源性转录因子导入体细胞或成体干细胞,使体细胞或成体干细胞转化为具有无限增殖潜能和定向分化能力、类似于胚胎干细胞的一类"人造干细胞"。来源于特定患者体细胞的iPSCs为医学研究提供了强有力的工具,并有可能为损伤修复的替代治疗提供细胞来源。现重点讨论iPSCs在重编程过程中最新研究进展并概述了iPSCs的临床应用前景。 Reprogramming of induced pluripotent stem cells （iPSCs） is an important breakthrough in the field of regenerative medicine recently. It is achieved through transduction of exogenous transcription fac- tors,into somatic cells,reprogramming the somatic ceils to embryonic stem cells -like cells with potencies of unlimited proliferation and pluripotent differentiation. IPSCs derived from somatic cells of patients represent a powerful tool for biomedical research and may provide a source for replacement therapies. Here the research progress of iPSCs reprogramming and its medical prospect were emphasized.
作者 汤翠菊 田有勇 张颖冬
机构地区 南京医科大学附属南京第一医院肿瘤科 南京医科大学附属南京第一医院神经内科
出处 《医学综述》 2011年第17期2564-2568,共5页 Medical Recapitulate
基金 江苏省政府留学奖学金资助(JS-2008-073)
关键词 诱导性多能干细胞 重编程 细胞模型 细胞治疗 Induced pluripotent stem cells Reprogramming Ceil model Ceil therapy
分类号 R-33 [医药卫生]
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参考文献39

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同被引文献23

  • 1胡利勇,陈定权.引文分析可视化研究[J].情报杂志,2004,23(11):78-79. 被引量：15
  • 2Lian Q, Zhang Y, Zhang J, et al. Functional Mesenchymal Stem Cells Derived From Human Induced Pluripotent Stem Cells Attenuate Limb lschemia in Mice[J]. Circulation, 2010, 121(9): 1113-1123.
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  • 8Grinnemo KH, Kumagai-Braesch M, Masson-Broberg A, et al. Human embryonic stem cells are immunogenic in allogeneic and xenogenei~ settings[J]. Reprod Biomed Online, 2006, 13(5): 712-724.
  • 9Swijnenburg RJ, Tanaka M, Vogel H, et al. Embryonic stem cell immunogenicity increases upon differentiation after transplantation into ischemic myocardium [J]. Circulation, 2005, 112 (9 Suppl)1 166- 172.
  • 10Muller A, Mehrkens A, Schafer DJ, et al. Towards an intraoperative engineering of osteogenic and vasculogenic grafts from the stromal vascular fraction of human adipose tissue [J]. Eur Cell Mater, 2010, 3 (19): 127-135.

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医学综述
2011年 第17期

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