利钠肽系统与高血压的研究进展

Advance in Research of Natriuretic Peptide System and Hypertension

利钠肽系统主要包括ANP、BNP、CNP及其受体NPRA、NPRB、NPRC,利钠肽通过与其受体结合从而发挥一系列生理作用如利钠、利尿、扩张血管而起降压作用。近年来研究发现,改变某一利钠肽或利钠肽受体成分表达,血压将出现不同程度改变(升高或下降);注射利钠肽可使血压下降。利钠肽系统在高血压诊治方面有可能在临床上受到日益重视。

The natriuretic pepfide system consists of ANP, BNP, CNP and their receptors NPRA, NPRB, NPRC ; the natriuretic peptides play the physiological role of lowering blood pressure as natriuretic, diuretic, and vasorelaxing through binding to the receptors. Recent studies found that changes in any component of the natriuretic peptide or natriuretic peptide receptors would increase or decrease blood pressure on different levels. Injection natriuretie peptide can lower blood pressure. Natriuretic peptide system may play an important role in the diagnosis and treatment of hypertension.