抗苗勒管激素在卵巢储备功能不同患者中的表达及相关性研究

The expression of serum anti-mullerian hormone Serum in different crowd and its correlation research

目的通过测定卵巢早衰(POF)、多囊卵巢综合征(PCOS)及正常对照组患者血清中抗苗勒管激素(AMH)水平,探讨血清AMH在不同卵巢储备功能患者中的不同表达。方法测定POF组(25例)、PCOS组(32例)和正常对照组(30例)血清中AMH水平,同时测定上述三组人群血清中卵泡刺激素(FSH)、黄体生成素(LH)、雌二醇(E2)、睾酮(T)及泌乳素(PRL)水平,并记录受试者的年龄、体重指数(MBI)、空腹血糖及胰岛素水平。结果①三组中POF血清AMH值最低,PLOS最高,且差异有统计学意义(P<0.05);②三组血清中FSH、LH、PRL、E2、T及AMH水平差异均有统计学意义(P<0.05),而这三组间年龄、MBI差异无统计学意义(P>0.05);③PCOS组血清中AMH与LH、T及MBI呈正相关性(P<0.05),与FSH和胰岛素抵抗指数无相关性。结论在不同卵巢储备功能患者中血清AMH表达不同,可能参与PCOS发生、发展,并与性激素合成失调有关。

Objective To measure serum AMH level in polycystic ovary syndrome（PCOS） patients,ovarian premature aging（POF） patients and controls and explore serum AMH in different function in patients with ovarian reserves expression.Methods AMH,follicle-stimulating hormone（FSH）,luteinizing hormone（LH）,eery estradiol（E2）,testosterone（T） and prolactin（PRL） level were determined in PCOS patients（n=32）,normal controls（n=30） and POF patients（n=25）.The age,MBI,blood glucose and insulin were recorded in all patients.Results There was no significant differences in age and MBI among three groups（P0.05）;The level of serum AMH was the highest in groups PCOS and it was the lowest in group POF.There was positive correlation between serum AMH and LH,T and MBI in PCOS patients.Conclusion There is different serum AMH level in different ovarian function reserves patients;AMH might be involved in PCOS occurrence,development,the synthesis and sex hormone imbalance.