非酒精性脂肪性肝病合并多囊卵巢综合征的相关性研究

The relationship between non-alcoholic fatty liver disease and metabolic profiles in women with PCOS

目的调查多囊卵巢综合征(PCOS)患者非酒精性脂肪性肝病(NAFLD)的发病情况,探讨NAFLD与PCOS患者代谢特征的相关性。方法选择PCOS组145例及对照组122例为研究对象,测定血清空腹血糖(FBG)、餐后2h血糖、空腹胰岛素(FINS)、餐后2h胰岛素、总甘油三酯(TG)、总胆固醇(Chol)、低密度脂蛋白(LDL)、高密度脂蛋白(HDL)、谷丙转氨酶(ALT)、谷草转氨酶(AST),以超声诊断脂肪肝。结果 PCOS组NAFLD的发生率明显高于对照组,差异有统计学意义(P<0.01);PCOS组的ALT、餐后2h INS、HOMA-IR高于对照组,差异有统计学意义(P<0.01)。PCOS患者伴与不伴NAFLD组比较,NAFLD组的ALT、餐后2h INS、BMI、FINS、HO-MA-IR、TG明显高于非NAFLD组,差异有统计学意义(P<0.05);NAFLD的发生率与ALT、餐后2 h INS、BMI、FINS、HOMA-IR呈正相关。结论 PCOS患者易患NAFLD,对肥胖及胰岛素抵抗的PCOS患者应常规进行转氨酶及肝脏超声检查。

Objective To explore the relationship between non-alcoholic fatty liver disease and metabolic profiles in women with PCOS by investigating the prevalence of NAFLD in polycystic ovary syndrome（PCOS） women.Methods The data of patients were acquired from 145 women with PCOS by Rotterdam consensus criteria and 122 women selected as controls,serum glucose and lipid profile,insulin,liver enzymes and body mass index（BMI） were measured.Fatty liver was diagnosed by ultrasound.Results Patients with PCOS showed a higher prevalence of NAFLD than that in control group.Serum ALT and serum insulin（2-hours after take oral glucose load） and HOMA-IR were significantly higher（P0.01） in women with PCOS compared to controls.Compared with patients without NAFLD,patients with NAFLD had significantly increased ALT,BMI,FINS,serum insulin（2-hours after take oral glucose load）,HOMA-IR and TG（P0.05）.The occurrence of NAFLD showed significant positive correlations with ALT,BMI,FINS,serum insulin（2-hours after take oral glucose load） and HOMA-IR.Conclusion PCOS appears to be more prone to develop NAFLD,PCOS women with IR and over weight should be screened for NAFLD.