摘要
以苯、甲基丙烯醇乙酸酯和氯丁酰氯为原料,经傅-克烷基化和傅-克酰基化反应,然后进行水解、氧化、偶联、硼氢化钠还原、成盐制得盐酸非索非那定,总收率为42.0%。该法具有收率高、成本低、环境友好、路线短等优点。
Fexofenadine hydrochloride was synthesized from benzene and methylallyl acetate via Frictel-Cratts alkylation, acylation, hydrolysis, oxidation, coupling and reduction. The overall yield was 42.0%. Comparing to the other methods, this synthetic route has advantages of high yield, low-cost and environmentally friendly.
出处
《精细化工中间体》
CAS
2011年第1期37-38,共2页
Fine Chemical Intermediates
基金
浙江省教育厅科研资助项目(Y200803040)
关键词
抗组胺药
非索非那定
合成
antihistaminic drug
fexofenadine
synthesis
