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奥沙利铂联合替吉奥方案治疗晚期胃癌的临床观察 被引量:10

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摘要 目的观察奥沙利铂联合替吉奥(SOX)方案治疗晚期胃癌患者的疗效。方法选择该科2008年9月至2010年2月收治的晚期胃癌患者12例,治疗第1天奥沙利铂130 mg/m2静脉滴注2 h;第1~14天餐后口服替吉奥40 mg/m2,每日2次;28 d为1个疗程,至少完成2个疗程。按实体瘤疗效评价标准(RECIST)评价客观疗效。结果部分缓解(PR)5例,病情稳定(SD)3例,病情进展(PD)4例。有效率(CR+PR)为41.67%,疾病控制率(CR+PR+SD)为66.67%。疾病进展时间(TTP)8.3个月,中位生存时间(MST)10.7个月。Ⅲ/Ⅳ度不良反应较少。结论 SOX方案治疗晚期胃癌不良反应较轻,患者耐受良好。
出处 《重庆医学》 CAS CSCD 北大核心 2011年第25期2581-2581,2596,共2页 Chongqing medicine
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  • 1Wagner AD,Grothe W,Haerting J,et al.Chemotherapy in advanced gastric cancer:A systematic review and meta-analysis based on aggregate data[J].J Clin Oncol,2006,24(18):2903-2909.
  • 2Ohtsu A.Chemotherapy for metastatic gastric cancer:past,present,and future[J].J Gastroenterol,2008,43(4):256-264.
  • 3Catalano V,Labianca R,Beretta GD,et al.Gastric cancer[J].Crit Rev Oncol Hematol,2009,71(2):127-164.
  • 4徐瑞华,滕开原.晚期胃癌化疗进展[J].癌症,2009,28(10):1108-1113. 被引量:98
  • 5Boku N,Yamamoto S,Fukuda H,et al.Fluorouracil versus combination of irinotecan plus cisplatin versus S-1 in metastatic gastric cancer:a randomized phase 3 study[J].Lancet Oncol,2009,10(11):1063-1069.
  • 6Koizumi W,Akiya T,Sato A,et al.Phase II study of S-1 as first-line treatment for elderly patients over 75 years of age with advanced gastric cancer:the Tokyo Cooperative Oncology Group study[J].Cancer Chemother Pharmacol,2010,65(6):1093-1099.

二级参考文献47

  • 1Parkin DM, Pisani P, Ferlay J. Estimates of the worldwide incidence of eighteen major cancers in 1985 [J]. Int J Cancer, 1993,54(4) :594-606.
  • 2Parkin DM, Bray FI, Devesa SS Cancer burden in the year 2000 [J] The global picture. Eur J Cancer, 2001,37(Suppl 8) : S4-S66.
  • 3Kamangar F, Dores GM, Anderson WF. Patterns of cancer incidence, mortality, and prevalence across five continents: defining priorities to reduce disparities in different geographic regions of the world [J]. J Clin Oncol, 2006,24(14) :2137-2150.
  • 4Pyrhonen S, Kuitunen T, Nyandoto P, et al. Randomised comparison of fluorouracil, epidoxorubicin and methotrexate (FEMTX) plus supportive care with supportive care alone in patients with non-resectable gastric cancer [J]. Br J Cancer,1995,71(3):587-591.
  • 5Murad AM, Santiago FF, Petroianu A, et al. Modified therapy with 5- fluorouracil, doxorubicin, and methotrexate in advanced gastric cancer [J]. Cancer, 1993,72(1):37-41.
  • 6Schethauer W, Kornek G, Zeh B. Palliative chemotherapy vs supportive care in patients with metastatic gastric cancer: a randomized trial [C]. Second International Conference on Biology, Prevention and Treatment of Gastrointestinal malignancies. Koln, 1995 : 65.
  • 7Glimelius B, Ekstrom K, Hoffman K, et al. Randomized comparison between chemotherapy plus best supportive care with best supportive care in advanced gastric cancer [J]. Ann Oncol, 1997, 8(2) : 163-168.
  • 8Wils JA, Klein HO, Wagener DJ, et al. Sequential high-dose methotrexate and fiuorouracil combined with doxorubicin-a step ahead in the treatment of advanced gastric cancer: a trial of the European Organization for Research and Treatment of Cancer Gastrointestinal Tract Cooperative Group [J]. J Clin Oncol, 1991,9(5): 827-831.
  • 9Webb A, Cunningham D, Scarffe JH, et al. Randomized trial comparing epirubicin, eisplatin, and fluorouraeil versus fluorouraeil, doxorubiein, and methotrexate in advanced esophagogastric cancer [J]. J Clin Oncol, 1997,15 ( 1 ) : 261-267.
  • 10Massuti B, Cervantes A, Aranda E, et al. A phase Ⅲ multicenter randomized trial in advanced gastric cancer: Fluorouracil +leucovorin + epirubicin + cisplatin (FLEP) vs Fluorouracilo + adriamycin+ methotrexate + leucovorin (FAMTX): response and survival [C]. Sixth International Congress on Anti- cancer Treatment, Paris, 1996.

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  • 1郭颖英,方伟虹,谢淑萍.替吉奥联合奥沙利铂治疗进展期胃癌疗效观察[J].浙江中医药大学学报,2010,34(5):783-783. 被引量:22
  • 2勒世联.不同化疗方案一线治疗老年晚期胃癌的近期疗效分析[J].中国生化药物杂志,2014,34(1):108-110. 被引量:9
  • 3吕晓娴,刘冰,张瑞丽.血清CEA和CA199及CA724联合检测对胃癌诊断的临床意义[J].中国肿瘤临床与康复,2007,14(1):26-28. 被引量:30
  • 4Kang HI, Chang HM, Kim TW, et al. A phase Ⅱ study of pacli- taxel and capecitabine as a first-line combination chemotherapy for advanced gastric cancer [J]. Br J Cancer, 2008, 98 (2) : 316- 322.
  • 5Mizoshita T, Kataoka H,Kubota E, et al. Gastric pheno-type signet-ring cell carcinoma of the stomach with multi-ple bone metastases effectively treated with sequentialmethotrexate and 5-fluorouracil [J]. Int J Clin Oncol,2008,13(4):373-376.
  • 6内科肿瘤学[M]. 人民卫生出版社, 2001.内科肿瘤学[M]人民卫生出版社,2001.
  • 7S. MacLellan,H. MacKay,J. Ringash,L. Jacks,Z. Kassam,T. Conrad,I. Khalili,A. Okrainec.Laparoscopic gastrectomy for patients with advanced gastric cancer produces oncologic outcomes similar to those for open resection[J]. Surgical Endoscopy . 2012 (7)
  • 8Andy Trotti,A.Dimitrios Colevas,Ann Setser,Valerie Rusch,David Jaques,Volker Budach,Corey Langer,Barbara Murphy,Richard Cumberlin,C.Norman Coleman,Philip Rubin.CTCAE v3.0: development of a comprehensive grading system for the adverse effects of cancer treatment[J]. Seminars in Radiation Oncology . 2003 (3)
  • 9Karnofsky DA,Burchenal JH.The clinical evaluation of chemotherapeutic agents in cancer. Evaluation of chemotherapeutic agents . 1949
  • 10Liu, Kun,Li, Guoli,Fan, Chaogang,Zhou, Changsheng,Li, Jieshou.Adapted Choi response criteria for prediction of clinical outcome in locally advanced gastric cancer patients following preoperative chemotherapy. Acta Radiologica . 2012

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