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大蒜素对人膀胱癌细胞BIU-87增殖和凋亡影响 被引量：2

Effects of Allicin on proliferation and apoptosis of BIU-87
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摘要 目的：观察大蒜素对人膀胱癌细胞BIU-87增殖和凋亡的影响。方法：采用细胞计数法（Cell counting kit-8，CCK-8）检测不同浓度的大蒜素对BIU-87细胞生长的影响；流式细胞仪Annexin V／PI双染法检测BIU-87细胞的凋亡率。结果：大蒜素作用于BIU-87细胞后，对其增值表现出了明显的抑制作用，且呈浓度依赖性；Annexin V／PI双染法检测显示，不同浓度的大蒜素均可诱导BIU-87细胞凋亡，与阴性对照组比较，差异有统计学意义（P〈0．05）。结论：大蒜素可抑制BIU-87细胞的增殖，诱导其凋亡。 Objective： To investigate the effects of Allicin on proliferation and apoptosis of BIU-87. Methods： Growth inhibition was measured by cell counting kit-8, the rate of apoptosis was detected by flow cytometry with Annexin-V/PI staining. Results： Allicin effectively inhibited the growth of BIU-87 in a concentration-dependent manner. Compared with the negative control group, the apoptosis of BIU-87 was significantly induced by different concentration of Allicin （P〈0. 05）. Conclusion： Allicin can inhibit the proliferation and induce apoptosis of BIU-87.
作者 王锋 伍静
机构地区 四川省隆昌县人民医院泌尿外科 四川省隆昌县人民医院妇产科
出处 《四川生理科学杂志》 2011年第3期104-105,共2页 Sichuan Journal of Physiological Sciences
关键词 大蒜素 膀胱癌 凋亡 Allicin Bladder cancer Apoptosis
分类号 R737.14 [医药卫生—肿瘤]
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参考文献7

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共引文献23

同被引文献41

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引证文献2

二级引证文献24

四川生理科学杂志
2011年 第3期

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