下呼吸道感染革兰阴性杆菌分布及耐药情况分析

Analysis of distribution and drug resistance among Gram-negative bacteria from lower respiratory tract infection

目的了解近两年我院下呼吸道感染患者革兰阴性杆菌的菌群分布及耐药情况。方法对我院下呼吸道感染住院患者的痰标本所分离的病原菌的菌群分布和耐药性进行统计分析。结果共收集2026株病原菌,其中革兰阴性杆菌1494株(73.9%),革兰阴性杆菌前五位分别是鲍曼不动杆菌344株(23.03%),铜绿假单胞菌334株(22.36%),肺炎克雷伯菌316株(21.15%),大肠埃希菌178株(11.91%)及阴沟肠杆菌90株(6.02%)。各类病原菌均存在不同程度的多药耐药现象。结论我院下呼吸道感染的革兰阴性杆菌均存在严重耐药问题,及时监测病原菌变化及耐药趋势对指导临床用药至关重要。

Objective To investigate the distribution and drug resistance among Gram-negative bacteria from respiratory tract infection and their drug resistance to help reasonably utilize the antibiotics.Methods A retrospective analysis for the antibiotic resistance of pathogens isolated from sputum sample of nosocomial lower respiratory tract infection was made in our hospital from Jan2009 to Dec2010.Results A total of 2026 pathogens were collected.Gram-negative bacilli were 1494（73.9%）.The most predominant Gram-negative bacteria isolates were Acinetobacter baumanii（344,23.03%）,pseudomonas aeruginosa（334,22.36%）,Klebsiella pneumoniae（316,21.15%）,Escherichia coli（178,11.91%）,Enterobacter cloacae（90,6.02%）.Conclussion It is importment that monitor the change of pathgen and the trends of antimicrobial resistame in guiding the antibiotic therapy.