小儿重症支原体肺炎免疫学临床研究

Clinical immunological investigation of severe mycoplasma pneumonia in children

目的探讨小儿重症支原体肺炎体液免疫变化。方法 108例重症支原体肺炎患儿的临床资料,分为普通治疗组(46例)和增加免疫方法治疗组(58例)。结果重症支原体肺炎患儿血清免疫球蛋白IgM水平明显高于轻症组,差异具有统计学意义(P<0.01);在治疗上免疫治疗组在热退时间、肺部啰音吸收时间、咳嗽缓解时间、胸片吸收时间、肺外并发症消失时间、住院时间均优于普通治疗组,差异均具有统计学意义(P值均<0.05)。结论重症支原体肺炎患儿较轻症组存在体液免疫功能异常,对于有适应症的患儿早期增加免疫治疗方法可缩短病程,减少并发症。

Objective To study humoral immunity in children with severe mycoplasma pneumonia,and explore the effects of immunological treatment.Method Analyze 108 cases clinical data of severe mycoplasma pneumonia in children,the humoral immune conditions compared with the mild group;the methods of treatment（removal of 4 patients were discharged） into conventional therapy group（46 cases） and immunity method treatment group（58 cases）.Result Serum IgM levels in children with severe mycoplasma pneumonia were significantly higher than the mild group,the difference was statistically significant（P〈0.01）;the treatment group increased immunological methods are superior to conventional therapy group in heat out time,pulmonary rales absorption time,cough relief time,chest X-ray absorption time,disappearance of pulmonary complications time,hospitalization time,these differences were statistically significant（all P〈0.05）.Conclusion There is humoral immune dysfunction in children with severe mycoplasma pneumonia than mild group,we should increase immunological therapy for those who have indications in the early time to shorten the course of the disease and reduce complications.