COPD患者HMGB1与肺功能的相关性分析

Correlative analysis Between HMGB1 and Lung function in patient of chronic obstructive pulmonary clisease

目的研究COPD病人在急性加重期和临床缓解期血中高迁移率族蛋白B1(HMGB1)、肺功能的变化及其相关性分析。方法分别测定COPD病人在急性加重期和经过治疗进入临床缓解期血清HMGB1的浓度及肺功能值(FEV1%、FEV1/FVC),数据用SPSS 13.0作统计分析。结果急性加重期HMGB1浓度值高于缓解期(P<0.05);急性加重期FEV1%低于缓解期(P<0.05);加重期和缓解期HMGB1浓度值和FEV1%呈直线负相关(P<0.05)。结论 1.HMGB1作为炎性分子,在COPD急性加重期血清浓度显著高于缓解期。2.在COPD中HMGB1浓度和肺功能明显相关,提示对于疾病严重程度的判断可能有一定意义。

Objective To investigate the change and correlation between HMGB1 and lung function in acute exacerbation and paracme of COPD. Methods To detect the level of HMGB1 in serum,lung function FEV1%, FEV1/FVC of COPD patient before and af- ter treatment. Result The level of HMGB1 in serum in acute exacerbation is higher than paracme （ P 〈 0. 05 ）. The level of FEV1% in a- cute exacerbation is lower than paracme （P 〈 0. 05 ）. The negative correlation is occurent between the level of HMGB1 and FEV1% （P 〈 0. 05 ）. Conclusion 1. The serum level of HMGB1 that was a inflammation molecule is significantly higher in acute exacerbation of COPD than paracme. 2. There is significant correlation between the level of HMGB1 and lung function（ FEV1% ） ,which predict potential benifet to judge severity of COPD.