摘要
目的探讨引起药物性肝损伤的原因、临床分型和预后。方法以"药物性肝损伤"、"药物性肝病"为关键词,检索2001～2011年中国期刊全文数据库,记录文献中患者性别、年龄、用药种类、临床分型和预后的相关数据进行总结分析。结果 88篇文献记录了9 355例患者性别,其中男性4 737例(50.6%),女性4 548例(49.4%)。平均年龄(42.3±13.1)岁。88篇文献记录了9 355例用药信息,其中中草药1 979例(21.15%)、抗结核药1 898例(20.29%)、抗微生物用药1 135例(12.13%)、解热镇痛用药740例(7.91%)、抗肿瘤药662例(7.07%)等。83篇文献记录8 552例临床分型,其中肝细胞型5 005例(62.73%),胆汁淤积型2 039例(23.84%),混合型1 508例(17.63%)。83篇文献记录了8 748例预后,其中治愈好转8 144例(95.23%),无效、自动出院、恶化及死亡604例(6.90%)。结论国内文献报道药物性肝损伤男女比例相当,导致肝损伤的前5类药物分别为中草药、抗结核药、抗微生物用药、解热镇痛用药、抗肿瘤药,损伤类型以肝细胞型居多,患者大多预后良好。
Aim To investigate the causes,clinical classification and prognosis of drug induced liver injury.Methods Drug-induced liver injury used as
出处
《安徽医药》
CAS
2011年第10期1312-1314,共3页
Anhui Medical and Pharmaceutical Journal
关键词
药物性肝损伤
中草药
抗结核药
case-analysis literatures on drug-induced liver injury from 2001 to 2011 Chinese periodical full-text database were searched
downloaded and gender
age
drugs
characters
clinical classifications and prognosis data were recorded.Results Among the recorded information
there were 4 737（50.6%）male and 4 548（49.0%） female
age ranging from 5 months to 92 years old with the average（42.3±13.1）years.Drugs of Chinese herbs
antituberculotics
antibiotics
and anti-hyperthyroidism drugs and antineoplastics were 1 979（21.15%）
1 898（20.29%）
1 135（12.13%）
740（7.91%）
662（7.07%）
and 382（4.08%）patients respectively.5 005（62.73%）cases were classified to hepatocellular type
2 039（23.84%）cases cholestasis type and 1 508（17.63%）cases mixed type.As for the prognosis
8 144（95.23%）cases cured or improved well
604（6.90%）cases no change or worse to dead.Conclusion It is reported in China that drug-induced liver injury occurred egually in males and females.Chinese herbs antituberculotics
non-steroid anti-inflammatory drugs antibiotics
anti-hyperthyroidism drugs
and the common hepatic injury was hepatocyte injury.Most patients were hepatocellular and generally the prognosis is good. Key words：drug induced liver injury
Chinese herbs
antituberculotics drugs
