60岁以上2型糖尿病并颈动脉硬化患者血清内脏脂肪组织源性丝氨酸蛋白酶抑制剂水平的测定

Association of serum visceral adipose tissue-derived serine protease inhibitor levels with carotid atherosclerosis in elderly patients with type 2 diabetes

采用酶联免疫吸附法对65例≥60岁合并颈动脉粥样硬化2型糖尿病患者（T2DM＋CA组），行血清内脏脂肪组织源性丝氨酸蛋白酶抑制剂（vaspin）测定，并与63例无动脉粥样硬化2型糖尿病患者（T2DM组）、55例止常对照者比较。T2DM＋CA组血清vaspin水平明显低于T2DM组：（0．23±0．13）与（0．41±0．16）μg/L，P〈0．01]，均明显低于正常对照者[（0．63-4-0．11）μg/L，P〈0．01，P〈0．05]。logistic回归分析冠示，高敏感C反应蛋白、稳态模型评估胰岛素抵抗指数是影响vaspin的独讧危险因素。提示低血清vaspin水平对老年2型糖尿病患者颈动脉粥样硬化的发牛有一定作用。

The serum levels of visceral adipose tissue-derived serine protease inhibitor （vaspin） were measured in 65 elderly type 2 diabetic patients with carotid atberuselerosis（ T2DM ＋ CA group）, 63 elderly type 2 diabetic patients without carotid atherosclerosis （T2DM group ） and 55 normal elderly individuals（NC group）by enzyme-linked immunosorbent assay. The results showed that the serum vaspin levels in T2DM ＋ CA group were, significantly lower than those in T2DM group [ （0. 23±0. 13 ）μg/L vs. （0. 41±0. 16） μg/L, P 〈 0. 01 ]. The serum vaspin levels in T2DM ＋ CA group and T2DM group were significantly lower than those in NC group respectively [ （0. 63±0. 11 ） μg/L, P 〈 0. 01 and P 〈 0. 05 ]. Logistic regression analysis showed that high sensitivety C-reactive protein and Homeostasis Model Assessment insulin resistance index （HOMA-IR） were negatively correlated with serum vaspin levels,which indicates that lower serum vaspin levels might be associated with the pathogenesis of carotid atherosclerosis in elderly type 2 diabetic patients.