B型尿钠肽早期诊断舒张性心力衰竭的临床价值

Significance of blood BNP in early diagnosis of diastolic heart failure

目的观察血浆B型尿钠肽(BNP)早期诊断舒张性心功能衰竭(DHF)的临床应用价值。方法选择2008年3月至2011年2月住院患者120例,其中有充血性心功能衰竭(CHF)临床症状的60例病人作为DHF组,选60例有同样基础疾病但无临床CHF症状的病人作为对照组,分别测定和比较两组病人血浆BNP值。结果 DHF组血浆BNP水平671±500 pg/ml,明显高于对照组29±13 pg/ml(P<0.01)。结论 DHF患者血BNP显著升高,在早期诊断具有应用价值。

Objective To observe the clinical significance of plasma B - type natriuretic peptide （BNP） in early diagnosis of diastolic heart failure （DHF）. Methods One hundred and twenty hospitalized patients including 60 cases of DHF with symptoms of clinical congestive heart failure （CHF） and 60 patients with same underlying disease but no clinical symptoms of CHF as control group. Plasma levels of BNP were measured and compared between these two groups. Results Plasma level of BNP in patients with heart failure was significantly higher than that in patients of control group （ 671 ±500 pg/ml in heart failure group and 29 ± 13 pg/ml in control group, P 〈0.01 ）. Conclusion Plasma level of BNP is significantly elevated in patients with DHF, hence determination of plasma level of BNP is useful in its early diagnosis.