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AMPA受体拮抗剂NS1209的合成

Synthesis of AMPA Receptor Antagonist NS1209
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摘要 以5-溴异喹啉为起始原料,经过9步反应合成了AMPA受体拮抗剂——NS1209,总产率37.3%,其结构经1H A AMPA receptor antagonist, NS1209, was synthesized from 5-bromo-isoquinoline by a nine-step reaction in overall yield of 37.3%. The structure was confirmed by 1H NMR and MS.
作者 杨海超 葛敏
出处 《合成化学》 CAS CSCD 北大核心 2011年第5期684-687,共4页 Chinese Journal of Synthetic Chemistry
关键词 异喹啉 AMPA受体拮抗剂 药物合成 isoquinoline AMPA receptor antagonist drug synthesis
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