肺炎克雷伯菌的耐药情况分析

Analysis of Antimicrobial Resistance of Klebsiella Pneumoniae in Nosocomial Infection

目的了解医院感染肺炎克雷伯菌的药敏耐药性与变化情况,为临床抗感染合理用药提供依据。方法对2009～2010年从医院感染患者临床标本中分离的肺炎克雷伯菌采用琼脂扩散法(K-B)进行药敏试验。结果 186株肺炎克雷伯菌中产ESBLs占28.5%,其产酶率呈上升趋势。结论应重视细菌培养,合理使用抗菌药物,根据药敏结果选择敏感抗菌药,对产EXBLs肺炎克雷伯菌应首选阿米卡星,亚胺培南,并应加强对产ESBLs菌株的监测。

Objective To investigate the multi-resistance toantibiotics of clinical isolated klebsiella pneumoniae.Methods A retrospective observational study was performed to analyze the relationship between antimicrobial use and bacterial resistance using Kirby and Bauer method.Results Pneumoniae infection was diagnosed in patients admitted to the hospital between 2009 and 2011.Of the 186 cases,53 cases（28.5%） were extended-spectrum β-lactamases（ESBLs） producing klebsiella pneumoniae,and ESBL expressing klebsiella pneumoniae were frequently obtained from samples of patients who attended the hospital.Conclusion The multi-resistance to antibiotics of clinical isolated klebsiella pneumoniae are widespread.It is important to control nosocomial infection using amikacin,imipenem and perform confirmatory tests to strengthen the detection of the epidemiology of ESBLs.