腰大池持续引流治疗重症颅内感染的疗效观察

The Efficacy Observation of Continuous Lumbar Drainage for the Treatment of Severe Intracranial Infection

目的观察探讨腰大池持续引流治疗重症颅内感染的临床疗效,总结其临床价值。方法选取我院2007年3月至2010年5月84例重症颅内感染的患者,随机分为观察组和对照组各42例,观察组采用腰大池持续引流治疗,对照组采用传统单纯静脉点滴抗生素治疗,观察对比两组治疗效果,记录相关数据进行统计学分析。结果经治疗后,观察组显效25例,有效10例,无效7例,发生并发症2例,占4.76%,总有效率83.3%;对照组显效17例,有效5例,无效20例,发生并发症8例,占19.0%,总有效率52.4%,两组治疗效果及并发症发生率差异显著(P<0.05),具有统计学意义。结论腰大池持续引流治疗重症颅内感染的临床疗效明显优于传统的抗生素治疗,且不良反应小,并发症发生率较低,值得在临床上合理推广应用。

Objective To observe the clinical efficacy of continuous lumbar drainage for the treatment of severe intracranial infection,to summarize its clinical value.Methods In our hospital from March 2007 to May 2010 84 cases of severe intracranial infection were randomly divided into the observation group and control group,42 cases in each group,the observation group was given continuous lumbar drainage treatment,the control group was given the traditional simple intravenous drip antibiotics treatment,to observe and compare the treatment effect of two groups,and to record the data for statistical analysis.Results After treatment,in the observation group there were 25 cases with marked effect,10 cases with effect,7 cases with no-effect,the complications occurred in 2 cases,accounting for 4.76%,the total effective rate was 83.3%;in control group there were 17 cases with marked effect,5 cases with effect,20 cases with no-effect,the complications occurred in 8 cases,accounting for 19.0%,the total effective rate was 52.4%,The treatment effect of two groups and incidence of complications were significantly different（P 0.05）,with statistical significance.Conclusion The clinical efficacy of continuous lumbar drainage for the treatment of severe intracranial infection was superior to conventional antibiotic treatment,and it has side effects,lower incidence of complications,so it deserves the clinical application.