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一类新的T细胞亚群“Th9”与炎症相关因子IL-9之间关系的研究进展 被引量：2

A Kind of New T Cell Sub-group Th9 and Inflammation Mutuality Factor
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摘要 辅助性T细胞从20年前的Th1和Th2报道至今,又增加了很多新成员,如Th17和Tregs等。这类辅助性T细胞是以分泌IL-9和IL-10为主。IL-9主要是与过敏性寄生虫感染、哮喘、遗传性过敏症和脑脊髓炎有关,因此,从细胞免疫学角度揭示了IL-9与Th9的关系,可以进一步达到治疗相关疾病的目的。就与之相关的研究进行了综述。 Twenty years ago,the Th1 and Th2 were reported.Up to now,the assistant T cell has increased lots of new member such as Th17 and Tregs and so on.This kind of assistant T cell mainly excreted IL-9 and IL-10.IL-9 is mainly related to the allergic parasites infection,asthma,hereditary hypersensitivity and encephalomyelitis.Therefore it revealed the relationship between IL-9 and Th9 from the angle of cellular immunity,and it could further achieve the aim of curing the relevance disease.The paper made the summarization for the related research.
作者 蔡家利 王亮 刘永 丁森 孙佳燕 扈国达
机构地区 重庆理工大学药学与生物工程学院
出处 《重庆理工大学学报（自然科学）》 CAS 2011年第8期21-24,共4页 Journal of Chongqing University of Technology：Natural Science
关键词 IL-9 TH9 CD4+T细胞 过敏性炎症 IL-9 Th9 CD4＋ T cell allergic inflammation
分类号 R75 [医药卫生—皮肤病学与性病学]
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参考文献18

  • 1Uyttenhove C, Simpson R J, Snick J Van. Functional and structural characterization of P40, a mouse glycoprotein with T-cell growth factor activity[ C ]//Proc. Natl. Acad. Sci. USA 85. [S. 1. ] :[s. n. ] ,1988:6934 -6938.
  • 2Yin T, Keller S R, Quelle F W, et al. Interleukin-9 in- duces tyrosine phosphorylation of insulin receptor sub- strate-I via JAK tyrosine kinases [ J ]. J Biol Chem, 1995,270:20497 - 20502.
  • 3Chang H C, Sehra S, Goswami R, et al. The transcription factor PU. I is required for the development of IL-9-pro- ducing T cells and allergic inflammation [ J ]. Nat Irnmu- nol,2010,11:527 - 534.
  • 4Staudt V, Bothur E, Klein M, et al. Interferon-regulato- ry factor 4 is essential for the developmental program of T helper 9 cells[ J]. Immunity ,2010,33 .. 192 - 202.
  • 5Huoltner L , Kolsch S, Stassen M, et al. In activated mast cells, IL-1 up-regulates the production of several Th2 - related cytokines including IL-9 [ J]. J Immunol, 2000,164:5556 - 5563.
  • 6Schmitt E , Brandwijk R Van, Snick J Van, et al. TCGF IIVP40 is produced by naive murine CD4 + T cells but is not a general T cell growth factor. Eur [ J ]. J Immunol, 1989,19:2167 - 2170.
  • 7Gessner A , Blum H, Rollinghoff M. Differential regula- tion of IL-9-expression after infection with Leishmania major in susceptible and resistant mice[ J]. Immunobiol- ogy, 1993,189:419 - 435.
  • 8Beriou G,Bradshaw E M, Lozano E,et al. TGF -beta induces IL-9 production from human Thl7 ceils [ J ]. J Immunol,2010,185:46 - 54.
  • 9Nowak E C , Weaver C T,Turner H, et al. IL-9 as a mediator of Thl7-driven inflammatory disease [ J]. J Exp Med,2009,206 : 1653 - 1660.
  • 10Veldhoen M, Uyttenhove C, van Snick Jet. Transforming growth factor-beta ' reprograms ' the differentiation of Thelper 2 cells and promotes an interleukin 9-producing subset [ J ]. Nat Immunol,2008,9 ( 12 ) : 1341 - 1346.

同被引文献45

  • 1Roesler B M, Costa S C, Zeitune J M. Eradication Treatment of Helicobacter pylori Infection: Its Importance and Possible Relationship in Preventing the Development of Gastric Cancer [J]. ISRN Gastroenterol, 2012, 2012: 935410.
  • 2Ernst M, Najdovska M, Grail D, et al. STA33 and STAT1 mediate IL-11-dependent and inflammation-associated gasaic tumorigenesis in gpl30 receptor mutant mice[ J]. J Clin In- vest, 2008, 118(5) : 1727.
  • 3Farahani R, Sherkat R, Hakemi M G, et al. Cytokines ( in- terleukin-9, IL-17, IL-22, IL-25 and IL-33 ) and asthma [J]. Adv Biomed Res, 2014, 3, 127.
  • 4Hufford M M, Kaplan M H. A gut reaction to IL-9 [ J ]. Nat Immunol, 2014, 15(7) : 599.
  • 5Licoua-Limon P, Henao-Mejia J, Temaun A U, et al. Th9 Cells Drive Host Immunity against Gastrointestinal Worm In- fection[J]. Immunity, 2013, 39(4) : 744.
  • 6Stephens G L, Swerdlow B, Benjamin E Thl7-derived cytokine that limits pathogenic activity in organ- specific autoimmune disease[ J ]. Eur J Immunol, 2011, 41 (4) : 952.
  • 7Carbo A, Olivares-Villagamez D, Hontecillas R, et al. Sys- tems modeling of the role of interleukin-21 in the maintenance of effector CD4 ^+ T cell responses during chronic Helicobacter pylori infection[J]. MBio, 2014, 5(4) : e01243.
  • 8Caruso R, Fina D, Paoluzi O A, et al. IL-23-mediated regu- lation of IL-17 production in Helicobacter pylori-infected gas- tric mucosa[J]. Eur J Immunol, 2008, 38(2): 470.
  • 9Yu H, Pardoll D, Jove R. STATs in cancer inflammation and immunity: a leading role for STAT3 [J]. Nat Rev Cancer, 2009, 9 ( 11 ) : 798.
  • 10Kabir S. The role of interleukin-17 in the Helicobacter pylori induced infection and immunity [ J ]. Helicobacter, 2011, 16 (1): 1.

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重庆理工大学学报（自然科学）
2011年 第8期

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