复方斑蝥胶囊联合CPT-11+CF+5Fu治疗晚期大肠癌的临床观察

Comparative study on treatment of advanced colorectal cancer by Banmao capsule combined with CPT-11+CF+5Fu regimen and by CPT-11+CF+5Fu regimen alone

目的观察复方斑蝥胶囊联合CPT-11＋CF＋5Fu化疗治疗晚期大肠癌的近期疗效和不良反应。方法将87例大肠癌患者随机分两组,对照组40例,单用CPT-11＋CF＋5Fu化疗方案,用法：CPT-11 150-180 mg/m^2,第1、8天,亚叶酸钙200 mg/m2静脉滴注2 h,第1、2天,5-氟脲嘧啶300 mg/m2静脉推注,第1、2天,600 mg/m^2持续微泵推入22 h,第1、2天,21天为1个周期;治疗组47例,在对照组治疗基础上加用复方斑蝥胶囊0.75 g,2次/日,连用15天。结果治疗组和对照组有效率分别是44.81%和33.6%,差异无显著性（P=0.3355）;KPS评分改善率分别是65.96%和40.00%,差异有显著性（P=0.0274）;1年生存率分别是53.19%和40.00%,差异无显著性（P=0.2193）,不良反应治疗组明显少于对照组,差异有显著性（P〈0.05）。结论复方斑蝥胶囊联合CPT-11＋CF＋5Fu方案治疗晚期大肠癌较单用CPT-11＋CF＋5Fu方案治疗疗效好,不良反应轻,生活质量改善明显,生存期有所延长。

Objective To evaluate the therapeutic efficacy and adverse reaction of Banmao capsule combined with CPT-11＋CF＋5Fu regimen for treatment of patients with advanced colorectal cancer and controlled with those of CPT-11＋CF＋5Fu regimen alone.Methods 87 patients were randomly devided into two groups.All the patients received CPT-11＋CF＋5Fu regimen,i,e.CPT-11 150-180 mg/m2 intravenous dropping in on day 1,C F 200 mg/m2 intravenous dropping and 5-FU 40 mg/m2 intravenous injection followed with 600 mg/m2 continuous infusion by micro-pump in 22 h on day 1 and 2,14 days as one course.Besides,to the treatment group（47 patients）,Banmao capsules was PO for 15 successive days,while to the control group（40 patients）,no additional medication was given.Results The response rate in the treatment group was 44.81% and in the control group 33.6%（P=0.3355）.The KPS score improving rate in the two groups was 65.96% and 40%,respectively（P0.005）.The 1year survival rate was 53.19% and 40.38%,respectively（P=0.2193）,and the adverse reaction presented in the treatment group was greatly less than that in the control group（P〈0.05）.Conclusion Banmao capsules in combining with CPT-11＋CF＋5Fu regimen can enhance the efficacy,reduce the adverse reaction of chemotherapy in treating advanced colorectal cancer,and could also improve the quality of life and prolong the survival time of patients.