炎性介质SAA和CRP术前评估卵巢癌的临床价值

Clinical value of inflammatory factors CRP and SAA in preoperative evaluation for ovarian cancer

目的探讨卵巢癌患者炎性介质CRP、SAA与肿瘤标记物CA125的相关性及其对卵巢肿瘤术前分期的价值。方法纳入150例卵巢癌患者于术前3天测定血清CA125、CRP和SAA的水平,分析炎性介质和肿瘤标记物的关系并与FIGO分期比较。结果术前SAA、CRP与CA125三者之间均有相关性(P<0.05)。在不同的FIGO分期之间差异有统计学意义,其中CRP和SAA与FIGO分期呈正相关。建立诊断进展期卵巢癌的ROC曲线,SAA的ROC曲线下面积AZ=0.993(P<0.001),CRP的AZ=0.922(P<0.05),CA125的AZ=0.871(P<0.05)。结论炎性介质和肿瘤标记物具有一定的相关性,应用SAA和CRP诊断进展期卵巢癌具有重要的临床价值。

Objective To investigate the correlation between inflammatory factors and tumor markers,and evaluate the application of them in the preoperative staging of ovarian cancer.Methods Levels of CRP,SAA,and CA125 were obtained from 150 ovarian cancer patients preoperatively in order to analyze the relationship within these biomarkers and with the FIGO stage.Results SAA showed correlation with CRP and CA125（P〈0.05）.Serum levels of CRP（P〈0.05）,SAA（P〈0.05） and CA125（P〈0.05）had statistically significant differences between pathological FIGO stages.Moreover CRP and SAA were positively correlated with FIGO stage.To set up the ROC curve for diagnosis of advanced ovarian cancer,the areas under the ROC curve of SAA,CRP,and CA125 were AZ=0.993（P〈0.05）,AZ=0.922（P〈0.05）,AZ=0.871（P〈0.05） respectively.Conclusion SAA and CRP are promising biomarkers for scanning advanced stage ovarian cancer.