氨甲喋呤联合米非司酮治疗未破裂型输卵管妊娠60例

The clinical analysis of Methotrexate combined with mifepristone in treatment of unruptured tubal pregnancy

目的探讨氨甲喋呤联合米非司酮治疗输卵管妊娠的临床效果。方法 120例未破裂型输卵管妊娠患者按入院先后随机分为观察组及对照组各60例,观察组:MTX 0.4 mg/kg×5天,一次肌肉注射,米非司酮50 mg/次,口服,1天2次,连服6天;对照组:MTX 0.4 mg/kg×5天,一次肌肉注射,同时口服安慰剂1片,2次/日,共5天。比较两组间的成功率及不良反应的差异。结果治疗成功率比较,观察组94.54%,对照组46.88%,组间差异具有显著性(P<0.05);两组间在不良反应方面差异无统计学意义(P>0.05)。结论氨甲喋呤联合米非司酮可提高治疗非破裂型输卵管妊娠的成功率而不增加不良反应,优于单用氨甲喋呤,值得临床推广应用。

Objective To explore the clinical effect of Methotrexate combined with mifepristone in the treatment of unruptured tubal pregnancy.Methods By order of admission,120 patients with unruptured tubal pregnancy were randomly divided into observation group and control group（n=60）.The observation group： MTX 0.4 mg/kg x 5 days,one intramuscular injection,mifepristone 50 mg/second,oral,1 day 2 times,and even served 6 days;the control group： MTX 0.4 mg/kg ×5 days,one intramuscular injection,at the same time an oral placebo,2 times/day for 5 days.the difference of success rate and adverse were compared between the two groups.Results The difference of success rate and adverse was significant between the two groups（P〈0.05）.The poor response difference was not statistically significant between the two groups.Conclusion Methotrexate combined with mifepristone can improve the success rate in treatment of unruptured tubal pregnancy without increasing adverse events than methotrexate alone,is worthy of clinical application.