胃癌患者血清总胆固醇、LDL及载脂蛋白B变化的相关研究

Correlated study of serum cholesterol,LDL and Apolipoprotein B changes in gastric carcinoma

目的比较胃癌、良性胃病患者与正常人血清中总胆固醇(TC)、低密度脂蛋白(LDL)及载脂蛋白B(ApoB)的含量变化,探讨胃癌患者血清LDL水平与胃癌临床参数之间的相关性。方法对177例胃癌、177例良性胃病患者及64例正常人采用日立7600-120E全自动生化分析仪测定外周血血脂及脂蛋白。用酶法测定血清TC,用沉淀法测定血清LDL及ApoB。结果胃癌组及良性胃病组血清TC、LDL和ApoB水平明显低于正常人组,差异有统计学意义(P<0.05);胃癌患者血清LDL水平与其性别、年龄及组织学类型无关,与肿瘤大小和浸润深度、淋巴结转移及TNM分期有一定的相关性。结论测定胃癌患者血清TC、LDL及ApoB水平有助于判断胃癌患者的病程及预后。

Objective To compare the content of serum total cholesterol,Low Density Lipoprotein（LDL） and Apolipoprotein B（ApoB） in patients with gastric cancer,benign gastric disease and normal subjects,and to investigate the correlation between the level of serum,LDL and clinical parameters of gastric cancer.Methods The blood lipid and lipoprotein of 177 cases with gastric cancer,177 cases with benign gastric disease patients and 64 cases of normal subjects were detected by the Hitachi 7600-120E automatic biochemical analyzer.The contents of serum total cholesterol were surveyed with enzymic method,and the contents of LDL and ApoB were surveyed with precipitation method.Results The contents of serum total cholesterol,LDL and ApoB in the group of normal subjects were higher than those in the groups of gastric cancer（P0.05）.No correlation was found between the level of serum,LDL and gender,age,histological type（P0.05）,and there was a statistically significant correlation between the level of serum LDL and the tumor size,invasive depth,lymph node metastasis,TNM stage.Conclusion Detection of the contents of serum total cholesterol,LDL and ApoB in patients with gastric cancer will be beneficial to the judgment of the course and prognosis of gastric carcinoma.