雷尼替丁对颅脑手术患者胃内pH的影响

Effect of Ranitidine on the intragastric pH in patients of brain surgery

目的为观察雷尼替丁对颅脑手术应激患者胃内pH的影响。方法将30例颅脑手术患者随机分为2组,对照组15例,术后不用雷尼替丁治疗;雷尼替丁组15例,术后予以雷尼替丁150 mg静脉滴注2次/d。2组均不用对血管有影响药物>2 h。所有患者于术前4 h开始胃内72 h pH监测。结果发现颅脑手术患者手术结束时胃内pH明显升高(P<0.01),但术后胃内pH显著下降(P<0.05)。雷尼替丁可阻断术后胃内pH下降,使术后胃内pH高于术前(P<0.05),与对照组比较,雷尼替丁组术后胃内pH明显升高(P<0.05)。结论颅脑手术应激患者存在术后胃酸高分泌,雷尼替丁能减少术后胃酸分泌。

Objective To investigate the effect of Ranitidine on the in tragastric pH in patients undergoing brain operation.Methods Thirty patients who received brain operation were randomly divided into two groups.After the operation,15 patients in the control group did not use Ranitidine,the other 15 patients in Ranitidine group received Ranitidine 150 mg intravenously twice daily.Drug affected blood vessel were inhibited beyond two hours in two groups.72-hour intragastric pH monitoring was carried out in all these patients 4 hours before the operation.Results In brain surgery patients,the intragastric pH increased at the end of the operation（P0.01）,and then decreased significantly after the operation（P0.05）.The level of intragastric pH in patients of Ranitidine group maintained a high level in postoperative period as compared with that before the operation（P0.05）.In Ranitidine group the postoperative intragastric pH was much higher than that in control group（P0.05）.Conclusion It suggests that there is hypersecretion of gastic acid in the brain operation patients.Ranitidine could inhibit such gastric acid secretion in postoperative period.