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乙酰肝素酶的mRNA表达与脑胶质瘤分级关系的研究 被引量：2

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摘要 脑胶质瘤是颅内最常见的恶性肿瘤[1],占颅内肿瘤的35.2%～61.0%。heparanase最早由Parish[2]等发现,是一个关键的胞外基质降解酶,它降解硫酸乙酰肝素和乙酰肝素蛋白聚糖上的聚糖侧链,在肿瘤浸润和转移中起重要作用。
作者 邵华明 王穗暖 李璐 张一
机构地区 江苏省常州市第一人民医院神经外科
出处 《实用临床医药杂志》 CAS 2011年第15期130-130,138,共2页 Journal of Clinical Medicine in Practice
关键词 人脑胶质瘤 乙酰肝素酶(heparanase) 荧光实时定量聚合酶链式反应
分类号 R739.41 [医药卫生—肿瘤]
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参考文献6

  • 1Dong J,Kukula A K,Toyoshima M,et al.Genomicorganization and chromosome localization of the newly identified human heparanase gene[J].Gene,2000,253:171.
  • 2Vlodavsky I,Elkin M,Pappo O,et al.Mammalian heparanase as mediator of tumor metastasis and angiogenesis[J].Isr Med Assoe J,2000,2(Suppl):37.
  • 3Mika mi S,Ohashi K,Usui Y,et al.Loss of syndecan-1and increased expression of heparanase in invasive esophageal carcinomas[J].JpnJ Cncer Res,2001,92(10):1062.
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同被引文献23

  • 1Sugiyama N,Gucciardo E,Lehti K. EphA2 bears plasticity to tumor invasion[J].CELL CYCLE,2013,(18):2927-2928.
  • 2Sugiyama N,Gucciardo E,Tatti O. EphA2 cleavage by MT1-MMP triggers single cancer cell invasion via homotypic cell repulsion[J].Cell Bio1,2013,(03):467-484.
  • 3Louis DN,Ohgaki H,Otmar D. The 2007 WHO Classification of tumours of the central nervous system[J].Acta Neuropathologica,2007,(02):97-109.
  • 4Blevins KS,Jeong JH,Ou M. EphA2 targeting peptide tethered bioreducible poly(cystamine bisacrylamide-diamino hexane) for the delivery of therapeutic pCMV-RAE-1 gamma to pancreatic islets[J].Journal of Controlled Release,2012,(01):115-122.
  • 5Thundyil J,Manzanero S,Pavlovski D. Evidence that the EphA2 receptor exacerbates ischemic brain injury[J].PLoS One,2013,(01):e53528.
  • 6Tognolini M,Giorgio C,Mohamed IH. Perturbation of the EphA2EphrinA1 system in human prostate cancer cells by colonic (Poly) phenol catabolites[J].Journal of Agricultural and Food Chemistry,2012,(03):8877-8884.
  • 7Zhou N,Zhao WD,Liu DX. Inactivation of EphA2 promotes tight junction formation and impairs angiogenesis in brain endothelial cells[J].Microvascular Research,2011,(07):113-121.
  • 8Russo S,Incerti M,Tognolini M. Synthesis and structure-activity relationships of amino acid conjugates of cholanic acid as antagonists of the EphA2 receptor[J].MOLECULES,2013,(10):13043-13060.
  • 9Chen HJ,Yuan BA,Zheng ZC. A novel vaccine containing EphA2 epitope and LIGHT plasmid induces robust cellular immunity against glioma U251 cells[J].CELLULAR IMMUNOLOGY,2011,(01):102-106.
  • 10Park JE,Son AI,Zhou RP. Roles of EphA2 in development and disease[J].Genes,2013,(03):334-357.

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实用临床医药杂志
2011年 第15期

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