妊娠期肝内胆汁淤积症96例临床治疗体会

Clinical analysis on intrahepatic cholestasis of pregnancy:A report of 96 cases

目的探讨妊娠期肝内胆汁淤积症(ICP)对母儿的影响。方法将2008年1月～2010年12月本院住院的96例ICP患者(观察组)与同期其他随机抽取的正常孕妇106名产妇(对照组)进行比较。结果 ICP早产儿(25%);胎儿宫内窘迫(31.58%);低体重儿(19.74%);围产儿死亡(3.95%);明显高于对照组(P<0.01)。剖宫产率(87.5%);产后出血(21.88%);明显高于对照组(P<0.01)。结论妊娠期肝内胆汁淤积症对母婴危害极大,应提高认识,加强孕期监护,提高围生儿生存率,降低产科并发症。

Objective To investigate the influences of intrahepatic cholestasis in the course of pregnancy（ICP） on mother and baby.Methods Retrospective analysis was made on the 96 cases of ICP（observation group） and the 106 cases of normal pregnant women（control group） in our hospital,in which the morbidity of premature delivery,fetal distress,low body weight,perinatal fetus and others were measured.Results For those that suffered ICP,the morbidity of premature delivery（25%）,fetal distress（31.58%）,low body weight（19.74%）,and perinatal fetus（3.95%） were significantly higher than the control group（P0.01）.Furthermore,the percentage of cesarean section（87.5%） and blood loss after delivery（21.88%） were also significantly higher than the control group（P0.01）.Conclusion Intrahepatic cholestasis of pregnancy can induce serious damage on mother and baby,which should be paid much attention to.Clinically,we should take intensive care of these patients to increase the survival rate of perinatal outcomes and decrease the obstetrical complications.