心钠素、血管紧张素Ⅱ与急性脑梗死的关系

The relationship between acute cerebral infarction and ANP and Ang-Ⅱ

目的通过观察急性脑梗死患者血浆心钠素和血管紧张素Ⅱ的变化,探讨二者与急性脑梗死之间的关系,期望这两者能够有助于临床医生判断患者病情、预后及指导临床治疗。方法选择首次发病并在24h以内到我院就诊、经头部MR检查证实的急性脑梗死患者60例,并选择同期在我院健康体检且排除了急性脑梗死的58例患者作为对照组。采用双抗体夹心法检测所有患者发病48h以内的血清心钠素和血管紧张素Ⅱ。结果 (1)脑梗死组的心钠素和血管紧张素Ⅱ水平高于对照组,且差异具有统计学意义(P<0.01);(2)在脑梗死组中,脑梗死合并高血压患者心钠素和血管紧张素Ⅱ的水平均高于单纯脑梗死患者,但差异无统计学意义(P>0.05)。结论心钠素和血管紧张素Ⅱ与脑组织损伤有关。在急性脑梗死患者中,血清中的心钠素和血管紧张素Ⅱ均显著升高。

Objective By observing the change of serum atrial natriuretic polypeptide（ANP） and angiotensin Ⅱ,we explore the correlation between the two in patients with acute cerebral infarction,and try to find out more effective indexes to judge the illness and prognosis,or to direct clinical treatment of patients for doctors.Methods 60 patients with acute ischemic stroke were chosen as cases,who had the first attack,and visited our hospital within 24h.They were confirmed by the head MR examination.At the same time,we choosed 58 patients without acute ischemic stroke as the control group.Using double-antibody sandwich assay in all patients within 48h of onset of serum atrial natriuretic peptide（ANP） and angiotensionⅡ（Ang-Ⅱ）.Results The levels of ANP and Ang-Ⅱ in cerebral infarction group were higher than control group,the difference between them was significant（P〈0.01）.The levels of ANP and Ang-Ⅱ in infarction with hypertension group were higher than simple cerebral infarction group,the difference between them wasn＇t significant（P〉0.05）.Conclusions ANP and Ang-Ⅱ are related to the brain tissue damage.In the acute ischemic stroke patients,they were significantly increased.