氨氯地平分别与替米沙坦及复方阿米洛利联合降压治疗对高血压患者左室质量指数的影响

The effects of Amlodipine Combined with Telmisartan and Compound amiloride respectively on left ventricular mass index in patients with hypertension

目的观察氨氯地平分别与替米沙坦及复方阿米洛利联合降压治疗对高血压患者左室质量指数的影响。方法 127例高血压病患者随机分为A组68例和B组59例。A组给予氨氯地平加替米沙坦治疗,B组给予氨氯地平加复方阿米洛利治疗,2组疗程均为2年。观察2组左室质量指数(LVMI)变化。结果 B组治疗后LVMI低于治疗前,差异有统计学意义(P<0.05),A组治疗前后LVMI变化及2组治疗后LVMI比较差异均无统计学意义(P>0.05)。结论氨氯地平联合复方阿米洛利降压更有助于降低左室质量指数,从而改善高血压对心脏靶器官的损害作用。

Objective To investigate the effects on of Amlodipine Combined with Telmisartan and Compound amiloride respectively on left ventricular mass index in patients with hypertension. Methods 127 cases of hypertension were ran- domly divided into A group （ n = 68 ） and group B （ n = 59）. Group A were given Amlodipine plus Telmisartan treatment, and group B were received Amlodipine plus Compound Amiloride treatment, Both groups were treated for 2 years. Left ventricular mass index （LVMI） changes in 2 groups were observed. Results After treatment, LVMI in group B was lower than that before treatment, and the difference was statistically significant （ P 〈 0.05 ） , but there was no significant difference in group A before and after treatment, and the difference showed no significance between the 2 groups （ P 〉 0.05 ）. Conclusion Amlodipine combined with compound Amiloride also can help to reduce blood pressure amd left ventricular mass index, thereby improving hypertension target organ damage of heart function.