摘要
目的探讨轮状病毒(RV)肠炎患儿细胞免疫状况,为防治婴幼儿RV肠炎开辟新思路。方法 RV肠炎患儿30例作为观察组,同期健康婴幼儿11例作为对照组。比较2组T淋巴细胞亚群变化。结果观察组CD3+、CD4+和CD4+/CD8+比值明显低于对照组,差异有统计学意义(P<0.01和P<0.05)。观察组重型患儿CD3+、CD4+低于轻型患儿,差异有统计学意义(P<0.01和P<0.05)。观察组CD3+、CD4+、CD4+/CD8+比值下降发生率高于对照组,差异有统计学意义(P<0.01和P<0.05)。结论因此,测定CD3+、CD4+细胞数及CD4+/CD8+比值对肠炎的预后、疗效和转归有辅助指导意义。
Objective To explore the cell immunity of infants with rotavirus （RV） enteritis and open up new train of thought for treating infants with RV enteritis. Methods 30 children with RV enteritis were grouped into observation group, 11 healthy infant served as control group. Compare the change of T-lymphocyte Subsets of 2 groups. Results The CD3^＋ ,CD4^＋ and CD4^＋/CD8 ^＋ ratio of the observation group were lower than those of the control group, and the differences were statistically significant（ P 〈0.01 和 P 〈 0.05 ）. The CD3^＋ ,CD4^＋ of.serious cases of the observation group were lower than those of the light cases, and the differences were statistically significant（ P 〈 0.01 和 P 〈 0.05 ）. The incidence of decline of CD3 ^＋ ,CD4^＋ and CD^＋/CD8^＋ratio of the observation group was higher than that of the control group, and the differences were statistically significant（ P 〈 0.01 和 P 〈 0.05 ）. Conclusion It is valuable for prognosis, effect, and conversion of enteritis to measure the level of CD3 ^＋ , CD4 ^＋ and the ratio of CD4^＋/CD8 ^＋
出处
《临床合理用药杂志》
2011年第18期30-31,共2页
Chinese Journal of Clinical Rational Drug Use
