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氯胺酮对大鼠神经病理痛的治疗作用及机制 被引量：1

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摘要 目的:研究氯胺酮对神经病理痛大鼠脊髓P2X7受体表达的影响。方法:采用免疫组化SABC法和RT-PCR检测神经病理性疼痛模型(CCI模型)大鼠脊髓P2X7受体蛋白及P2X7-mRNA表达变化。结果:神经病理痛大鼠脊髓P2X7受体及mRNA表达明显增加(P<0.05),给予氯胺酮干预后P2X7受体及mRNA表达有所下降,但不能达到术前水平(P<0.05)。结论:CCI模型大鼠氯胺酮能部分缓解神经病理性疼痛,其作用机制与直接或间接降低脊髓神经胶质细胞P2X7受体表达有关。
作者 周兴 刘菊英
机构地区 武汉大学人民医院麻醉科 湖北医药学院附属太和医院麻醉科
出处 《医学信息（中旬刊）》 2011年第9期4295-4296,共2页 Medical Information Operations Sciences Fascicule
基金 湖北省科技厅项目2060402796
关键词 氯胺酮 神经病理性疼痛 P2X7
分类号 R441.1 [医药卫生—诊断学]
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参考文献5

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  • 4Fulgenzi A, Ticozzi P, Gabel CA, et al. Periodate oxidized ATP (oATP) reduces hyperalgesia in mice: involvement of P2X7 receptors and implications for therapy. Int J Immunopathol Pharmacol, 2008 Jan - Mar, 21 ( 1 ) : 61 -71.
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同被引文献27

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医学信息（中旬刊）
2011年 第9期

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