高血压脑出血的尼莫地平早期应用研究

Research of Early Treatment of Nimodipine on hypertensive intracerebral hemorrhage

目的:观察钙离子拮抗剂尼莫地平对高血压脑出血的临床作用。方法:对75例高血压脑出血患者分治疗组38例和照组37例。各组入院后即开始泵入尼莫地平,持续14d;对照组除不用尼莫地平外,其他同治疗组。对2组患者进行治疗前后颅内血肿大小及周围水肿的变化。结果:尼莫地平治疗组血肿及周围水肿面积较对照组显著减小(P<0.05)。结论:尼莫地平能促进水肿和血肿吸收,抑制脑水肿形成,并且在高血压脑出血治疗中尼莫地平可以被作为一种有效的药物应用。

Objective：To observe the clinical effect of calcium-channel blocker nimodipine in the treatment of hypertensive cerebral hemorrhage（HCH）.Methods：Total 75 patients with HCH were randomly divided into treatment group and control group,38 cases as treatment group.Nimodipine was pumped continuously into the patients in treatment group 6 hours after operation for 14 days.The treatment of control group was similar to treatment group except nimodipine.The absorption of hemorrhage and edema were observed and compared between the two groups by blind trial.Results：The area of edema （according CT）and volume of hematoma were detected were significantly diminished（P0.05）.Conclusion：Nimodipine can benefit the absorption of hemorrhage and edema,and Nimodipine could be used as a effective medicine in HCH treatment.