参附注射液治疗脓毒性休克的应用研究

Research on Septic Shock Treated with Injection of ShenFu

目的:研究参附注射液治疗脓毒休克时的临床影响。方法:将脓毒性休克患者93例随机分为治疗组和对照组,两组均进行早期液体复苏、纠正酸中毒、选用敏感抗生素、必要时使用血管活性药物及激素等基础治疗和积极后续器官功能支持治疗,治疗组全程同时加用参附注射液。结果:休克复苏成功率治疗组、对照组分别为73.08%、42.22%,差异呈显著性(P<0.05);血管活性药物及激素的使用差异呈显著性(P<0.05);治疗组中需再次复苏者较对照组明显减少(P<0.05);后续治疗中治疗组患者ALT、AST、Cr的改变与对照组相比差异呈显著性(P<0.05)。结论:参附注射液治疗脓毒性休克安全有效,且能减少血管活性药物及激素的使用,对重要器官功能有保护作用,从而减少其并发症,降低病死率。

Objective：To research the climical offection of septic shock were treated with Injection of ShenFu.Methods：93 cases of septic shock were randomly divided into tow groups：treatment group and control group.Bosh groups accepted early liquid resuscitation,treatment of acidosis,usage of sensitive antibiotics and usage f vasoactive drugs and glucocorticoid if necessary.The treatweat group accepted Injection of ShenFu treatment at the same time.Results：The success rate of resuscitation in septic shock were 73.08% and42.22% in treatment group and control group.There are significant differences between the two groups （P0.05）.The dose of vasoactive drugs and glucocorticoid are siguificant different（P0.05）.Those who need double resuscitation were much less in treatment group than in control group （P0.05）.The change of ALT、AST and Cr were siguificant different between the two groups in the following treatment （P0.05）.Conclusion：Injeetion of ShenFu is safe and effective for the treatment of septic shock.It can decrease the usage of vasoactive drugs and glucocoticoid,and protect the function of vital organs.It also decrease the complications and mortality rate.