摘要
瓜环具有"内疏水、外亲水"的特殊分子结构,可与多种有机物发生主-客体相互作用而形成自组装分子胶囊或超分子实体,使其在环境、医药、化学分离和材料改性等方面具有广泛的应用前景.本文结合本组工作,并参考国内外文献,综述了瓜环在药物载体及药物传输方面的研究进展,并对瓜环在药物领域的发展进行了展望.
Many drug delivery systems are based on the ability of certain macrocyclic compounds,such as cyclodextrins(CDs),to act as molecular containers for pharmaceutical agents in water.Cucurbit[n]urils(Q[n]) which have the unique structure with hydrophobic central cavity and hydrophilic carbonyl group portals,are a class of molecular containers that bind to a variety of cationic and neutral species with high affinity and therefore show great promise as a drug delivery system.In this review,we traced the development of cucurbit[n]urils in the drug carriers and drug delivery.The studies in the literature and in our laboratory reveal that cucurbit[n]urils can improve drug solubility,stability and specificity.Furthermore,Q[n]s molecule can be linked together to form a nanocapsule shell that can trap drug compounds inside.The outer surface of such capsules can be decorated with other species by plugging them into the cavities of the hollowed-out pumpkins.At last,the prospect of the cucurbituril in drug delivery was also presented.
出处
《高等学校化学学报》
SCIE
EI
CAS
CSCD
北大核心
2011年第9期2022-2031,共10页
Chemical Journal of Chinese Universities
基金
国家自然科学基金(批准号:20972034)
贵州省省长资金(批准号:黔省专合字(2009)103号)
贵州省科技厅自然科学基金(批准号:黔科合J字[2009]2288号)
贵州省教育厅自然科学基金(批准号:黔教科2010013)
贵州大学引进人才项目[批准号:贵大人基合字(2009)023号]资助
关键词
瓜环
药物载体
药物传输
Cucurbit[n]uril
Drug carrier
Drug delivery