瓜环类超分子药物载体的研究进展

Progress of Cucurbit[n]urils in Drug Delivery System

瓜环具有"内疏水、外亲水"的特殊分子结构,可与多种有机物发生主-客体相互作用而形成自组装分子胶囊或超分子实体,使其在环境、医药、化学分离和材料改性等方面具有广泛的应用前景.本文结合本组工作,并参考国内外文献,综述了瓜环在药物载体及药物传输方面的研究进展,并对瓜环在药物领域的发展进行了展望.

Many drug delivery systems are based on the ability of certain macrocyclic compounds,such as cyclodextrins（CDs）,to act as molecular containers for pharmaceutical agents in water.Cucurbit[n]urils（Q[n]） which have the unique structure with hydrophobic central cavity and hydrophilic carbonyl group portals,are a class of molecular containers that bind to a variety of cationic and neutral species with high affinity and therefore show great promise as a drug delivery system.In this review,we traced the development of cucurbit[n]urils in the drug carriers and drug delivery.The studies in the literature and in our laboratory reveal that cucurbit[n]urils can improve drug solubility,stability and specificity.Furthermore,Q[n]s molecule can be linked together to form a nanocapsule shell that can trap drug compounds inside.The outer surface of such capsules can be decorated with other species by plugging them into the cavities of the hollowed-out pumpkins.At last,the prospect of the cucurbituril in drug delivery was also presented.