超氧化物歧化酶化学模拟的新进展

Recent Progress in Superoxide Dismutase Mimics

超氧化物歧化酶在生物体内具有催化超氧离子自由基(O-2.)歧化反应的特异性,具有抗氧化、抗癌症及抗炎症等重要生理学作用.超氧化物歧化酶的化学模拟引起人们广泛的研究兴趣.本文系统综述了超氧化物歧化酶模拟物在设计合成及应用上的新进展.

Superoxide dismutases（SOD） are ubiquitous in living systems.These enzymes serve as a vital role in defending oxygen-utilizing life forms from oxidative damage.The natural superoxide dismutases can catalyze the dismutation of the free radical superoxide and have efficacy in disease states,partly,mediated by superoxide,such as oxidative stress,cancer,and inflammation.The practical use of superoxide dismutases in biological systems is problematic due to difficulties associated with the systematic infection of protein.The tremendous researches were made in this area in recent years on the rational design and synthesis of low molecular weight catalysts which mimic a natural SOD enzyme function.Low molecular weight mimics could have significant advantages over SOD enzymes such as lack of immunogenic response,longer half-life in the blood,improved access to cells and intercellular space,potential for oral delivery,and low costs.This review described the recent progress of superoxide dismutase mimics on the design,synthesis and application.