甘精胰岛素联合格列美脲在2型糖尿病初始胰岛素治疗中的疗效观察

Effects of Glargine with Amaryl and Neutral Protamine Hagedorn Insulin in Patients with type 2 Diabetic

目的:观察甘精胰岛素(Glargine)联合格列美脲(Amaryl)治疗口服药控制不佳的2型糖尿病患者的疗效及安全性。方法:选用口服降糖药控制差的2型糖尿病患者46例,随机分为A组采用甘精胰岛素联合格列美脲治疗,B组采用中效低精蛋白胰岛素联合格列美脲,持续观察治疗12周,比较两组空腹血糖(FBG)、餐后2 h血糖(2hPBG)、糖化血红蛋白(HbAlc)、空腹胰岛素(FINS)、空腹血糖达标时间、低血糖出现次数,监测肝肾功能、血常规及体重增加情况。结果:甘精胰岛素组FBG达标时间、HbAlc水平及出现低血糖次数、体重增加值均低于中效低精蛋白胰岛素组(P<0.05)。结论:口服降糖药疗效差的2型糖尿病患者应用甘精胰岛素(Glargine)联合格列美脲(Amaryl)治疗,有更显著的降糖效果,临床应用安全,病人依从性更好。

Objective：To compare fluctuation of blood glucose in type 2 diabetic patients treated by Glargine combined with Amaryl and Neutral protamine hagednrn insulin. Methods：46 patients with type 2 diabetic were randomly divided into two groups： Glargine groups （ n = 23 ） and Neutral protamine hagedorn insulin group （ n = 23 ） to compare Std. deviation, Range of blood glueose and insulin quantity , incidence of hypoglycemia. Results：Glargine group was obviously lower thau NPH group in incidence of hypoglycemia and insulin quantity, Glargiue gn）up decreased greater than the NPH groups on FBG. Conclusions：Take fall blood sugar drug poor effects of the patients, Application Glargine join Amaryl treatment, Curative effect is distinct, Clinical application patient safety, compliance with better perfolxnance.