环磷酰胺冲击治疗儿童难治性肾病综合征疗效观察

Effect of Cyclophosphamide Impulsive Therapy on Children with Nephritic Syndrome

目的:观察环磷酰胺(CTX)冲击治疗儿童难治性肾病综合征的疗效。方法:42例难治性肾病综合征患儿,予环磷酰胺10 mg/kg.d.加入生理盐水或5%葡萄糖液100 mL中静滴,连用2 d,每隔2周1次,共6～9次,总累积剂量120～180 mg/kg,同时口服强的松。结果:冲击治疗后血浆总蛋白及白蛋白有不同程度的升高,冲击治疗前后有显著性差异;24 h尿蛋白定量有明显降低;冲击治疗过程中除部分患儿出现胃肠道症状外,几乎无其他副作用。结论:环磷酰胺冲击治疗儿童难治性肾病综合征安全、有效。

Objective：To observe the effect of cyclophosphamide impulsive therapy on children with nephritic syndrome. Methods ：42 chlidren with nephritic syndrome were chosen and given intravenous stosstherapy with CTX. CTX was administered in a dose of 10 mg/kg · d on the first 2 clays of two weeks and for 6 - 9 times in all. Accumulated dose were 150 mg/kg · d averagely 120- 180 mg/kg · d. At the same time Prenisone was used by oral. Results： Before and .after treatment of plasma total pfotein and albumin have different degrees, compared with each other the difference was signifi- cantly. Except a few patients had gastrointestinal tract symptom, there were almost no other untoward reaction. Conclusions：Intravenous stosstherapy with CTX is a safe and effective method to treat children with nephricte.